Yueju Pills first appeared in ZHU Zhenheng's Danxi's Experiential Therapy(Dan Xi Xin Fa) during the Yuan Dynasty and is praised as the “holy medicine for relieving depression”.It is used to treat the six types of stagnation，i.e.，qi，blood，phlegm，fire，dampness，and food.Yueju Pills are widely applied in clinical practice for various conditions，including those of the nervous system(such as anxiety，depression，insomnia，and dementia)，digestive system(gastroesophageal reflux disease，atrophic gastritis，non-alcoholic fatty liver disease，functional dyspepsia，etc.)，and cardiovascular system(coronary heart disease，hypertension).The therapeutic mechanisms of Yueju Pills may involve alleviating inflammation，improving oxidative stress，reducing anxiety and depression，enhancing cognition，lowering blood lipids，stabilizing plaques，controlling blood sugar，protecting the gastric mucosa，and promoting gastrointestinal motility.