| 引用本文:邓素玲 马灵筠.骨痹消对大鼠佐剂性关节炎血清中TNF-α、IL-1β、IL-6水平的影响[J].世界中医药,2008,3(5):. |
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| 骨痹消对大鼠佐剂性关节炎血清中TNF-α、IL-1β、IL-6水平的影响 |
| Effect of Gu Bi Xiao on TNF-а, IL-1β, IL-6 in Rats with AIA |
| 投稿时间：2008-06-23 |
| DOI： |
| 中文关键词: 强直性脊柱炎/中医药疗法 @ 骨痹消 |
| English Keywords:Ankylosing Spondylitis/ Chinese Medical Therapy @ Gu Bi Xiao |
| 基金项目: |
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| 中文摘要: |
| 目的：观察骨痹消对关节损伤的防治作用及机制，为AS的治疗提供实验依据。方法：取Wistar雄性大鼠40只，随机分为4组，每组10只。分别为模型组、中药组、罗非西布组、对照组。用佛氏佐剂注射于模型组、中药组、罗非西布组大鼠左后足掌皮下，造佐剂性关节炎模型；对照组注射等量生理盐水。中药组和罗非西布组分别灌胃给中药水煎剂2ml／200g、罗非昔布2ml／200g(0.2mg)，模型组和对照组灌胃给自来水2ml／200g，每天灌胃1次。结果：在使用中药骨痹消方后，大鼠血清TNF-α、IL-1β、IL-6水平均显著下降。结论：中药骨痹消对大鼠佐剂性关节炎有一定的治疗作用，可减轻炎症反应和关节肿胀，改善关节功能，其机制可能与下调TNF-α、IL-1β、IL-6，抑制炎症反应有关。 |
| English Summary: |
| To explore preventive and treatment effects of Gu Bi Xiao on joint injuries and its mechanism, providing lab data for Ankylosing Spondylitis treatment.Methods:Forty Wister male rats were randomly divided into 4 groups (n=10): the model group, Chinese medicine group, Rofecoxib group, the three of which established AIA model by injecting Freud' s Adjuvant into the plantar surface of left hind paw, and control group injected with same volume of Sodium Chloride. Chinese medicine decoction (2mL/200g) and Rofecoxib (2mL/200g), or tap water (2mL/200g) were administered respectively to four groups by gavages daily.Results:TNF-а, IL-1β, IL-6 in Rats with AIA decreased markedly after administration of Gu Bi Xiao. Conclusion:Gu Bi Xiao is effective in the treatment of AIA by relieving inflammation and joint swelling and improving joint functions, which may have something to do with down-regulation of TNF-а, IL-1β, IL-6. |
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