| 引用本文:周娟娟1，祁俊1，秦亚东2.玉夏胶囊质量标准研究[J].世界中医药,2016,(01):. |
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| 玉夏胶囊质量标准研究 |
| Research of Quality Standard of Yuxia Capsule |
| 投稿时间：2015-03-19 |
| DOI：10.3969/j.issn.1673-7202.2016.01.040 |
| 中文关键词: 玉夏胶囊 质量标准 薄层鉴别 防己诺林碱 粉防己碱 |
| English Keywords:Yuxia capsule Quality standards TLC Fangchinoline Tetrandrine |
| 基金项目:安徽省芜湖市科技计划2009年度科技项目（编号:卫生5—1） |
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| 中文摘要: |
| 目的：建立医疗机构制剂玉夏胶囊的质量控制标准。方法：采用薄层色谱（TLC）法对玉夏胶囊中防己、莱菔子进行定性鉴别研究；采用高效液相色谱（HPLC）法对玉夏胶囊中的粉防己碱和防己诺林碱进行定量研究。结果：薄层色谱中阴性样品均无干扰，专属性强；防己诺林碱在24～84 μg/mL范围内峰面积与浓度呈现良好的线性关系，r=0.9992，平均回收率为102.3%，RSD=2.57%；粉防己碱在34.5～207.0 μg/mL范围内峰面积与浓度呈现良好的线性关系，r=0.9999，平均回收率为102.3%，RSD=2.57%。结论：本实验建立的方法简便、快捷、准确、重现性好，可用于玉夏胶囊的质量控制。 |
| English Summary: |
| To establish the quality standard of Yuxia capsules. Methods: Radix stephaniae tetrandrae(Fang Ji)and Radish Seed(Laifuzi) were identified by TLC and the contents of Tetrandrine and Fangchinoline were detremined by HPLC. Results: The TLC chromatography was exclusive and the blank test showed no interference. The detremination of fangchinoline kept good linear relation in the content ranges of 24～84 μg/mL r =0.9992. The average recovery test of fangchinoline was 102.3%, RSD=2.57%.The detremination of tetrandrine kept good linear relation in the content ranges of 34.5～207.0 μg/mL, r =0.9999. The average recovery test of tetrandrine was 102.3%, RSD=2.57%. Conclusion:The established qualitative methods are simple, fast, accurate and with good reproducibility which can be used for the quality control of Yuxia capsules. |
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