世界中医药

目的：观察大承气汤对急性中毒的临床疗效以及预后情况。方法：选取我院2013年4月至2015年4月期间接诊的80例急性中毒患者作为研究对象，将其进行随机分组，每组各40人，其中对照组患者采用常规治疗方案，研究组患者在对照组的基础上联合大承气汤进行治疗。检测并记录2组患者的ICU住院时间、机械通气时间、排便时间、苏醒时间和2组患者治疗前、治疗后6 h、12 h、24 h、48 h的血清胆碱酯酶活性；2组患者呼吸衰竭、合并其他器官损害、ICU死亡等情况，并对其结果进行比较分析。结果：研究组患者的ICU住院时间、苏醒时间等均明显低于对照组患者，差异具有统计学意义（P<0.05）；治疗前，2组患者的血清胆碱酯酶活性没有明显的区别，差异无统计学意义（P>0.05），经过治疗，2组患者的血清胆碱酯酶活性均有明显的升高，差异显著，具有统计学意义（P<0.05），且研究组患者的升高程度明显强于对照组，差异具有统计学意义（P<0.05）；研究组患者的呼吸衰竭、合并其他器官损害的发生率明显低于对照组患者，差异显著，具有统计学意义（P<0.05），而2组患者的ICU死亡率差异无统计学意义（P>0.05）。结论：中药大承气汤可以显著改善急性中毒患者的临床症状，加快毒物的排出，缩短患者的治疗时间，具有临床应用价值，值得推广。

English Summary:

To observe the curative effect and prognosis of acute poisoning when treated with Major Purgative Decoction. Methods: Total 80 cases of acute poisoning patients in our hospital from April 2013 to April 2015 were randomly divided into two groups, each group having 40 people. The control group were treated with conventional treatment; the study group were treated with Major Purgative Decoction on the basis of the control group. ICU hospitalization time, recovery time; 6 h, 12 h, 24 h, 48 h of serum cholinesterase activity, respiratory failure, damage to other organs, ICU deaths were recorded in the two groups before and after treatment. Results: ICU hospitalization time, recovery time of the study group were significantly shorter than the control group (P<0.05）; after treatment, the serum cholinesterase activity of the two groups rose obviously, but the study group had significant better results (P<0.05）; respiratory failure, organ damage incidences in the study group were significantly less than the control group(P<0.05）; and the differences of ICU mortality of patients in the two groups were not statistically significant (P>0.05).Conclusion: Major Purgative Decoction can significantly improve the clinical symptoms of patients with acute poisoning, speed up the process of discharging the poison, and shorten the treating time, which has clinical application value, and worthy of promotion.

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