| 引用本文:王小龙1，徐彬1，周雷1，马俊杰1,2，李智强1，徐增柏1.扶正抗癌方联合化疗治疗肝胃不和型胃癌效应观察[J].世界中医药,2016,(08):. |
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| 扶正抗癌方联合化疗治疗肝胃不和型胃癌效应观察 |
| Clinical Effect and Mechanism of of Healthy qi Reinforcing and Anti-cancer Decoction in Treatment of Stomach Cancer with Liver-stomach disharmony syndrome |
| 投稿时间：2016-06-21 |
| DOI：10.3969/j.issn.1673-7202.2016.08.017 |
| 中文关键词: 扶正抗癌方 中医药 化疗 肝胃不和 胃癌 |
| English Keywords:Healthy qi Reinforcing and Anti-cancer Decoction Chinese medicine Chemotherapy Liver-stomach disharmony syndrome Stomach cancer |
| 基金项目:宿迁市科技项目——扶正抗癌方治疗肝胃不和型胃癌临床疗效及机制研究（编号：Z201517） |
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| 中文摘要: |
| 目的：观察扶正抗癌方联合西药治疗肝胃不和型胃癌的疗效及机制。方法：将41例胃癌患者随机分为治疗组和对照组，均给予多西他赛40 mg/m2，第1，8天，静脉滴注1 h，并常规给予抗过敏预处理；奥沙利铂75 mg/m2，第1天，静脉滴注2 h；21 d为1个周期，共化疗2个周期。对照组21例在此基础上加服安慰剂；治疗组20例在上述治疗的基础上加用扶正抗癌方，治疗1个疗程(40 d)。疗程结束后，判定疗效，观测临床症状、症状积分、不良反应及免疫指标等。结果：治疗组治疗总有效率显著高于对照组(P<0.05)，免疫功能相关指标优于对照组(P<0.05)，KPS评分(卡氏生活质量评分)显著优于对照组(P<0.05)。结论：扶正抗癌方联合西药治疗肝胃不和型胃癌疗效满意，无严重不良反应，可显著改善免疫功能及生存状况，值得推广应用。 |
| English Summary: |
| To explore the clinical curative effect and mechanism of Healthy qi Reinforcing and Anti-cancer Decoction in the treatment of stomach cancer in liver-stomach disharmony syndrome. Methods: Total 41 cases of patients with stomach cancer were randomly divided into treatment group and control group, both groups were given intravenous drip Docetaxel with 40 mg/m2 for 1 hour at 1 st and 8th days′ treatment, with an allergy conventional pretreatment; Oxaliplatin 75 mg/m2, intravenous drip for 2 hour at the first day; the chemotherapy lasted for 2 session, each session lasted for 21 d. The 21 cases in the control group received placebo on the base of the treatment; The 20 cases in treatment group also received Healthy qi Reinforcing and Anti-cancer Decoction for 1 session (40 d). The curative effect, clinical symptoms, symptom integral, adverse reactions, and immune index were observed. Results: The total effective rate of the observation group was significantly higher than control group (P<0.05), the related parameters of immune function were better than control group (P<0.05), KPS score (carr′s quality of life score) was significantly better than control group (P<0.05).Conclusion:The results of the Healthy qi Reinforcing and Anti-cancer Decoction combined western medicine therapy is satisfied in the treatment of stomach cancer with liver-stomach disharmony syndrome, with no serious adverse reactions, and can significantly improve the immune function and survival condition, which is worthy of popularization and application. |
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