| 引用本文:王邦才1，王玲玲1，袁建芬2，朱奇雄3，潘东梅1，王培劼1，王杰1，王益1.泄浊化瘀方治疗非酒精性脂肪性肝炎的临床研究[J].世界中医药,2016,(08):. |
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| 泄浊化瘀方治疗非酒精性脂肪性肝炎的临床研究 |
| Clinical Observation on Expelling Turbid and Removing Stagnation Formula in the Treatment of Nonalcoholic Steatohepatitis |
| 投稿时间：2015-06-18 |
| DOI：10.3969/j.issn.1673-7202.2016.08.020 |
| 中文关键词: 非酒精性脂肪性肝炎 浊瘀内积型 泄浊化瘀方 临床观察 |
| English Keywords:Nonalcoholic steatohepatitis (NASH) Turbid phlegm obstruction type Expelling turbid and removing stagnation formula Clinical research |
| 基金项目:宁波市社会发展项目(编号：2013C50051) |
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| 中文摘要: |
| 目的：观察泄浊化瘀方治疗非酒精性脂肪性肝炎的临床疗效，探讨泄浊化瘀疗法的作用机制。方法：将200例符合非酒精性脂肪性肝炎是西医诊断标准，中医分型属于浊瘀内积型患者，采用随机数字表法，分为观察组和对照组。观察组用泄浊化瘀方，对照组用硫普罗宁片合壳脂胶囊，疗程为8周。观察患者治疗前后的主要临床症状及体征，血清谷丙转氨酶（ALT）、谷草转氨酶（AST）、γ-谷氨酰转移酶（GGT）、总胆固醇（TC）、三酰甘油（TG）含量，肝脏B型超声及上腹部CT，比较2组的疗效。结果：2组总疗效比较，治疗组总有效率94%，对照组总有效率75%，差异有统计学意义（P<0.05）。2组患者经治疗后检测肝功能与血脂，与治疗前比较均明显改善，差异有统计学意义(P<0.05)；组间比较差异有统计学意义(P<0.05)。结论：泄浊化瘀方治疗浊瘀内积型非酒精性脂肪性肝炎，不但可以改善患者临床症状及体征，而且能有效恢复肝功能和改善血脂，对非酒精性脂肪性肝炎有较好疗效，总有效率达94%。 |
| English Summary: |
| To investigate the clinical efficacy and therapeutic mechanism of expelling turbid and removing stagnation formula in treating nonalcoholic steatohepatitis(NASH).Methods:Two hundred patients with NASH of turbid phlegm obstruction type were randomly divided into the treatment group(100) and control group(100). The treatment group was given expelling turbid and removing stagnation formula, while the control group was given N-(2-Mercaptopropionyl) glycine capsule. Both of the two groups were treated for 8 weeks. The changes of alanine aminotransferase (ALT), aspartate aminotransferase(AST), gamma glutamyl transferase(GGT), cholesterol total(TC), triglyceride(TG)levels, brightness-mode ultrasound of liver and the CT of the epigastrium were observed and compared.Results:The total effective rate of the treatment group and control group were 94% and 75% respectively(P<0.05). The levels of ALT, AST, GGT, TC, TG decreased significantly after the treatment in both groups (P<0.05) and the difference between the groups were significantly different(P<0.05).Conclusion:Expelling turbid and removing stagnation formula can improve liver function and reduce blood lipids, which has great efficacy in treating phlegm obstruction type of NASH with a total effective rate of 94%. |
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