| 引用本文:李金明，郑国昌，姜军.雷公藤多苷联合盐酸坦索罗辛缓释胶囊对慢性非细菌性前列腺炎患者炎性反应因子水平的影响及其疗效[J].世界中医药,2016,(08):. |
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| 雷公藤多苷联合盐酸坦索罗辛缓释胶囊对慢性非细菌性前列腺炎患者炎性反应因子水平的影响及其疗效 |
| The Clinical Efficacy of thtripterygium Glycosides Combined with Tamsulosin Hydrochloride Sustained Release Capsules in theTreatment of the Patients with Chronic Abacterial Prostatitis and the Effect on the Levels of Inflammatory Cytokine |
| 投稿时间：2015-11-18 |
| DOI：10.3969/j.issn.1673-7202.2016.08.029 |
| 中文关键词: 雷公藤多苷 盐酸坦索罗辛缓释胶囊 慢性非细菌性前列腺炎 疗效 炎性反应因子 |
| English Keywords:Thtripterygium glycosides Tamsulosin Hydrochloride Sustained Release Capsules Chronic abacterial prostatitis Efficacy Inflammatory factor |
| 基金项目:邢台市科研项目(编号:2013032) |
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| 中文摘要: |
| 目的:探讨雷公藤多苷联合盐酸坦索罗辛缓释胶囊对慢性非细菌性前列腺炎患者疗效观察及对患者炎性反应因子水平的影响。方法:选取2013年1月至2014年12月期间我院泌尿科收治的慢性非细菌性前列腺炎患者126例按照随机数字表法随机分为观察组(n=63)和对照组(n=63)。观察组患者用雷公藤多苷联合盐酸坦索罗辛缓释胶囊治疗;对照组患者单用盐酸坦索罗辛缓释胶囊治疗。2组均以4周为1个疗程,连续治疗2个疗程。观察2组患者疗效、治疗前后NIH-CPSI各项指标评分变化、最大尿流率和EPS-WBC、炎性反应因子水平变化及安全性评价。结果:观察组总有效率明显高于对照组(P<0.05);2组排尿症状、疼痛与不适、生活质量、NIH-CPSI总分治疗后明显低于治疗前(P<0.05);观察组排尿症状、疼痛与不适、生活质量、NIH-CPSI总分治疗后明显低于对照组(P<0.05);2组最大尿流率治疗后明显高于治疗前(P<0.05),EPS-WBC明显低于治疗前(P<0.05);观察组最大尿流率治疗后明显高于对照组(P<0.05),EPS-WBC明显低于对照组(P<0.05);2组TNF-α和IL-8明显低于治疗前(P<0.05);观察组TNF-α和IL-8明显低于对照组(P<0.05);2组均未见明显不良反应。结论:雷公藤多苷联合盐酸坦索罗辛缓释胶囊对慢性非细菌性前列腺炎患者疗效明显,可降低炎性反应因子水平,具有重要研究意义。 |
| English Summary: |
| To investigate clinical efficacy of thtripterygium glycosides combined with Tamsulosin Hydrochloride Sustained Release Capsules in the treatment of the patients with chronic abacterial prostatitis and the effect on the levels of inflammatory cytokine.Methods:The 126 cases of patients with chronic abacterial prostatitis were trreated from January 2013 to December 2014,which were randomly divided into observaion group(n=63) and control group(n=63) according to random number table.The observation group were treated with thtripterygium glycosides combined with Tamsulosin Hydrochloride Sustained Release Capsules and the control group were treated with Tamsulosin Hydrochloride Sustained Release Capsules alone.For 4 weeks as a course,and both group were treated continuously for two course.To observe the efficacy,the changes of NIH-CPSI score before and after treatment,maximum flow rate,the changes of the EPS-WBC and the levels of inflammatory cytokine and the safety evaluation.Results:The total effective rate in the observtation group were significantly higher than that of the control group(P<0.05);after treatment,the CPSI-U,pain and discomfort,quality of life and the NIH-CPSI in both groups were significantly lower than that of the before(P<0.05); the CPSI-U,Pain and discomfort,Quality of Life and the NIH-CPSI in the observation group were signifiantly lower than that of the control group(P<0.05);the maximum flow rate in both groups were significantly higher than that of before(P<0.05) and the EPS-WBC were significantly lower than that of th before(P<0.05); the maximum flow rate in the observation group were significantly higher than that of the control group and the EPS-WBC were significantly lower than that of the cotrol group(P<0.05);the TNF-α and IL-8 in both groups wer significantly lower than that of the before(P<0.05);the TNF-α and IL-8 in the observation group were significantly lower than that of the control group(P<0.05).There was no severe adverse effects in two groups.Conclusion:The clinical efficacy of thtripterygium glycosides combined with Tamsulosin Hydrochloride Sustained Release Capsules in the treatment of the patients with chronic abacterial prostatitis is significant,can reduce the levels of inflammatory cytokine,has fatal research significance. |
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