| 引用本文:孟瑞荣.小儿肺热咳喘口服液联合阿奇霉素治疗肺炎支原体性肺炎的疗效观察[J].世界中医药,2016,(08):. |
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| 小儿肺热咳喘口服液联合阿奇霉素治疗肺炎支原体性肺炎的疗效观察 |
| Observation on the Effect of Xiao′er Feire Kechuan Oral Solution with Azithromyci on Mycoplasma Pneumoniae Pneumonia |
| 投稿时间：2015-08-25 |
| DOI：10.3969/j.issn.1673-7202.2016.08.034 |
| 中文关键词: 阿奇霉素 小儿肺热咳喘口服液 肺炎支原体性肺炎 |
| English Keywords:Azithromycin Xiao′er Feire Kechuan oral solution Mycoplasma pneumoniae pneumonia |
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| 中文摘要: |
| 目的：为了探索治疗儿童肺炎支原体感染的中西医结合的可靠方法，将小儿肺热咳喘口服液联合阿奇霉素治疗，探索这种方法的可行性以及其临床价值。方法：本研究具有随机性、前瞻性、平行性、开放性以及阳性药物对照等多种特性。将2014年5月到2015年5月符合排除标准以及入选标准的发热伴有咳嗽的疑似下呼吸道感染的肺炎支原体性肺炎儿童作为本实验研究对象，随机分为对照组和治疗组，治疗组使用小儿咳喘口服液联合阿奇霉素处理，对照组仅使用阿奇霉素。收集所有患儿的咽拭子标本或者血清以及临床病例资料。检测咽拭子标本中的MP23rRNA使用巢式PCR方法，检测血清中的MP卡尼采用乳胶凝集法或者ELISA法。对于血清阳性或者PCR阳性的患有下呼吸道感染的儿童的病例资料进行分析总结以及统计学分析。结果：对于血清肺炎支原体-抗体或者肺炎支原体-DNA阳性的80例肺炎支原体下呼吸道感染的肺炎支原体性肺炎，符合入选标准的患儿进行分析，其中对照组42例，治疗组38例。经统计分析，2组患儿在治疗前的病情方面、性别以及年龄方面的差异并无统计学意义（P>0.05）。治疗结束后，按病程对2组患儿的临床疗效进行分析，对照组患儿的咳嗽减轻时间,咳嗽消失时间以及退热时间均比治疗组儿童的咳嗽减轻时间咳嗽消失时间以及退热时间，差异均具有统计学意义（P=0.006，0.024，<0.001）。结论：阿奇霉素联合小儿肺热咳喘口服液对于儿童肺炎支原体下呼吸道感染的肺炎支原体性肺炎治疗效果优于单纯使用阿奇霉素，小儿肺热咳喘口服液可以作为临床上治疗儿童肺炎支原体下呼吸道感染的辅助用药。 |
| English Summary: |
| To observe the clinical effect of Xiao′er Feire Kechuan oral solution with Azithromyci in the treatment of mycoplasma pneumoniae infection, and thus explore a integrated way to treat such a disease. Methods: To collect patients with fever accompanied by cough(suspected lower respiratory infection of mycoplasma pneumoniae pneumonia) who enrolled in the hospital between May 2014 to May 2015. Then divide them randomly into treatment group and control group. Eighty child patients were concluded in the study, with 42 cases in the control group and 38 cases in the treatment group. There are no statistical difference among disease severity, gender, and age between the two groups(P>0.05). The treatment group was given Xiao′er Feire Kechuan oral solution with Azithromycin and the control group was given Azithromycin sorely. Apply nested PCR detection and the method of ELISA test to determine MP23rRNA. Results: Anti-febrile time, cough reduce duration and recover duration in the treatment group are all shorter than that of the control group, and the difference was statistically significant(P=0.006, 0.024,<0.001). Conclusion: In treating children′s MP lower respiratory tract infection, Xiao′er Feire Kechuan oral solution combined with Azithromyci shows more curative effect than Azithromyci alone. Xiao′er Feire Kechuan oral solution can be used as an auxiliary medicine in treating such a disease. |
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