世界中医药

目的:探讨调补肺肾法治疗慢性阻塞性肺疾病(COPD)稳定期的临床疗效,评价治疗COPD稳定期患者的预后作用。方法:选取2014年1月至2015年6月在我院就诊的COPD稳定期患者84例,采用随机方法将患者分为观察组(42例)和对照组(42例),观察组给予常规治疗和口服调补肺肾方药,而对照组仅给予常规治疗,观察2组临床疗效及综合预后情况。结果:2组治疗后中医症候总积分较治疗前均有所下降,而观察组较对照组下降幅度明显(P<0.05);观察组治疗总有效率为92.86%,明显高于对照组的64.29%,治疗组疗效优于对照组(P<0.05);2组治疗后肺功能均有所改善,其中观察组FEV1和FEV1/预计值(%)、FVC和FVC/预计值(%)等指标改善情况优于对照组(P<0.05);观察组治疗后呼吸困难情况、6 min行走距离和BODE评价总分均较治疗前有改善(P<0.05),而对照组治疗后6 min行走距离和BODE评价总分亦较治疗前有所改善(P<0.05),但呼吸困难情况改善不明显(P>0.05),观察组治疗后呼吸困难情况、6 min行走距离和BODE评价总分均较对照组治疗后明显改善(P<0.05)。观察组治疗后各免疫指标、生活质量指标和急性发作次数较对照组均有所改善(P<0.05)。结论:调补肺肾法能有效治疗COPD稳定期患者,改善患者预后情况。

English Summary:

To investigate the clinical effect of tonifying lung and kidney method on the treatment of chronic obstructive pulmonary disease in stable stage and to evaluate the prognosis of patients with COPD on stable phage. Methods: Eighty-four patients with stable COPD, who received treatment in the hospital from 2012 August to 2014 April in were collected and randomly divided into the observation group (42 cases) and the control group (42 cases). The observation group was given conventional treatment plus orally-taking tonifying lung and kidney prescription, while the control group was only given conventional treatment. Clinical efficacy and prognosis of two groups were observed. Results: The TCM pattern total score of the two groups were decreased after treatment compared to those before the treatment, while those of the observation group was more significant than those of the control group decreased (P<0.05). The total effective rate of the observation group was 92.86%, significantly higher than 64.29% in the control group. The curative effect of the treatment group surpasses that of the control group (P<0.05). The lung function of two groups were improved after treatment, including FEV1/ the expected value (%), FVC and FVC/ predicted value (%) and other indicators of the observation group were better than those of the control group (P<0.05). Respiratory difficulties, 6 min walking distance and BODE evaluation score of both the observation group and the control group after treatment was better improved compared to those before the treatment. Differences in the observation group showed statistic significance (P<0.05), while except for improvement in dyspnea condition (P>0.05), differences of other indicators in the control group showed statistic significance (P<0.05). Respiratory difficulties, 6 min walking distance and BODE evaluation score of the observation group and the control group after treatment was improved more remarkably compared to those of the control group (P<0.05). The immune indexes, indicators of the quality of life and frequency of acute attack of the observation group after treatment were improved (P<0.05).Conclusion: Tonifying lung and kidney method is effective in the treatment of COPD patients in stable stage and may improve the prognosis.

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