| 引用本文:赵强，刘雅男.基于“胃不和则卧不安”理论治疗功能性胃肠病伴焦虑失眠的临床疗效及患者生活质量影响[J].世界中医药,2016,(08):. |
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| 基于“胃不和则卧不安”理论治疗功能性胃肠病伴焦虑失眠的临床疗效及患者生活质量影响 |
| The Application of “Disharmony of Stomach leads to Insomnia” Theory in the Treatment of Common Functional Gastrointestinal Diseases Combined with Anxiety and Insomnia and its Effect on Patients′ Life Quality |
| 投稿时间：2015-08-19 |
| DOI：10.3969/j.issn.1673-7202.2016.08.040 |
| 中文关键词: 功能性胃肠病 胃不和则卧不安 辨证施治 焦虑失眠 临床疗效 生活质量 |
| English Keywords:Common Functional Gastrointestinal Diseases Disharmony of stomach leads to insomnia TCM syndrome differentiation treatment Anxiety and insomnia Clinical curative effect Quality of life |
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| 目的：观察中医辨证施治功能性胃肠病伴焦虑失眠的临床疗效及对患者生活质量影响。方法：对符合标准的90例患者按随机数字表法以1:1的比例随机分为观察组和对照组个45例，治疗组根据中医辨证分型给予中药治疗，1剂/d，3次/d，每次剂量约250 mL，30 d为1个疗程；对照组给予奥美拉唑肠溶胶囊20 mg，1次/d，口服；莫沙必利胶囊5 mg口服，3次/d；劳拉西泮0.5 mg睡前口服，1次/d，30 d为1个疗程。结果：2组患者治疗前后消化道症状积分、HAMA评分、HAMD评分变化比较，治疗组明显优于对照组；2组消化道症状改善方面比较，治疗组总有效率91.11%；对照组总有效率77.78%，治疗总有效率比较（χ2=6.873.P=0.001<0.05），差异有统计学意义；2组焦虑症状改善方面比较，治疗组总有效率97.78%；对照组总有效率84.45%，2组总有效率比较（χ2=8.367,P=0.030<0.05）差异有统计学意义；2组患者抑郁症状改善方面比较，治疗组总有效率86.66%；对照组总有效率77.78%，2组总有效率比较（χ2=4.359,P=0.024<0.05），差异有统计学意义，2组治疗后PSQI评分比较，治疗组（8.94±3.05），对照组（12.76±4.58），2组比较，差异有统计学意义（P<0.05）。结论：与单纯对照组相比较，中医辨证治疗临床疗效显著，患者依存性高，值得推广。 |
| English Summary: |
| To observe the curative effect of “Disharmony of Stomach leads to Insomnia” theory on Common Functional Gastrointestinal Diseases combined with anxiety and insomnia and its effect on patients′ quality of life. Methods: Ninety patients were randomized into observation group and control group(n=45). The treatment group was given Chinese medicine according to different TCM(Traditional Chinese Medicine) syndromes, one dose a day, three times a dose. Each dose is about 250 mL, lasting for 30 days.The control group was given Omeprazole enteric capsules 20 mg Po qd; Mosapride 5 mg Po t id; Lorazepam 0.5 mg Po qn, lasting for 30 days. Results: The digestive tract symptoms integral, HAMA, HAMD of the treatment group were better than that of the control group. In regards to digestive tract symptoms improvement rate, the total effective rate of treatment group was 91.11% and the total effective of control group was 77.78% and the difference was statistically significant. In regards to the relief of anxiety, the total effective of treatment group was 97.78% and the total effective of control group was 84.45%, and the difference was statistically significant(χ2=6.873, P=0.001<0.05). In regards to depression relief rate, the total effective of treatment group was 86.66% and that of the control group was 77.78%, and the difference was statistically significant(χ2=8.367, P=0.030<0.05). Also, the difference of PSQI scores between the two groups were significantly different(the treatment group was（8.94±3.05）, the control group was（12.76±4.58）, P<0.05. Conclusion: Compared with simple control group, the clinical curative effect is obvious by TCM syndrome differentiation treatment, and the patients have high dependency. It is worthy of clinical application. |
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