| 引用本文:庞娟1，叶婷婷2，舒朝霞3.复方青黛胶囊治疗寻常型银屑病的疗效及对血清炎性反应因子的影响[J].世界中医药,2017,(06):. |
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| 复方青黛胶囊治疗寻常型银屑病的疗效及对血清炎性反应因子的影响 |
| Efficacy of Compound Qingdai Capsule in the Treatment of Psoriasis Vulgaris and Its Effect on Serum Inflammatory Factors |
| 投稿时间：2017-03-24 |
| DOI：10.3969/j.issn.1673-7202.2017.06.020 |
| 中文关键词: 银屑病 复方青黛胶囊 炎性反应因子 血流变学 疗效 |
| English Keywords:Psoriasis Compound Qingdai Capsule Inflammatory factors Hemorheology Efficacy |
| 基金项目:国家自然科学基金项目（编号:81071330）——犬小孢子菌膜蛋白PQ-LRP基因全长cDNA的克隆及功能分析 |
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| 中文摘要: |
| 目的:探讨复方青黛胶囊治疗寻常型银屑病的疗效及对患者生命质量、血清炎性反应因子、血流变学指标的影响。方法:选取2015年6月至2016年2月绵阳市中医医院收治的寻常型银屑病患者90例并随机分为观察组与对照组,每组45例。对照组给予迪银片治疗,观察组在对照组的基础上加用复方青黛胶囊治疗,4周为1个疗程,2组均连续治疗2个疗程。评价2组患者的临床疗效,采用PASI指数评价2组患者皮损面积和病情严重程度,采用皮肤病生命质量量表（DLQI）评价2组患者生命质量,检测并比较治疗前后2组患者炎性反应因子、血流变学指标水平。结果:观察组总有效率为97.78%（44/45）,显著高于对照组的82.22%（37/45）（P<0.05）;治疗后2组PASI指数和DLQI评分均较治疗前显著下降（P<0.01）,且观察组显著低于对照组（P<0.05或P<0.01）;治疗后2组IL-2、IL-8和IFN-γ水平均较治疗前显著降低,IL-4水平较治疗前显著升高,且组间差异有统计学意义（P<0.05或P<0.01）;治疗后2组全血（低、中、高切）黏度、血浆黏度、红细胞比容均较治疗前显著降低（P<0.05或P<0.01）,且观察组显著低于对照组（P<0.05或P<0.01）。结论:复方青黛胶囊治疗寻常型银屑病的疗效确切,可显著降低机体炎性反应因子水平,同时可改善患者血流变学指标水平,进而降低患者皮损面积,促进患者早日恢复。 |
| English Summary: |
| To investigate the effect of Compound Qingdai Capsule in the treatment of psoriasis vulgaris and its effect on quality of life, serum inflammatory factors and hemorheology. Methods: Ninety patients with psoriasis vulgaris were randomly divided into treatment group and control group with 45 cases in each group. The control group was treated with Diyin Tablet, while the treatment group was additionally treated with Compound Qingdai Capsule with 4 weeks as a course and the two groups were treated for 2 courses. The clinical efficacy of the two groups was evaluated and the PASI index was used to evaluate the lesion area and severity of the two groups. Quality of life of the two groups was evaluated by the skin disease quality of life scale （DLQI） and the levels of inflammatory factors and hemorheology were measured and compared between the two groups before and after treatment. Results: The total effective rate was 97.78% （44/45） in the treatment group, which was significantly higher than that in the control group （82.22%, 37/45） （P<0.05）. The PASI and DLQI scores of the two groups were significantly lower than those before the treatment （P<0.01） and the treatment group was significantly lower compared with the control group （P<0.05 or P<0.01）. The IL-2, IL-8 and IFN-γ in 2 group were significantly lower than those before the treatment, IL-4 was significantly higher （P<0.05 or P<0.01）, and the difference between the two groups was significant （P<0.05 or P<0.01）. The plasma viscosity, hematocrit and hematocrit were significantly lower after the treatment （P<0.05 or P<0.01） and significantly lower than those of the control group （P<0.05 or P<0.01）. Conclusion: Compound Qingdai Capsule is effective in the treatment of psoriasis vulgaris, which may significantly reduce the level of inflammatory factors and improve hemorheology level, reduce skin lesions and promote early recovery. |
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