世界中医药

目的:探讨肾衰宁胶囊治疗早中期慢性肾衰竭（CRF）患者的临床疗效及患者肾功能指标的变化。方法:选取2012年3月至2014年12月本院收治的早中期CRF患者82例,随机分为对照组及观察组,每组41例。对照组在常规治疗的基础上给予包醛氧淀粉治疗,观察组在对照组的基础上联合肾衰宁胶囊治疗,2个月为1个疗程,2组患者均连续治疗2个疗程。统计2组患者临床疗效及主要临床症状积分,检测治疗前后2组患者Hb、Alb、24 h UPQ及UA的变化;比较治疗前后2组患者肾功能指标。结果:观察组临床总有效率为85.37%,较对照组的46.34%显著提高（P<0.01）;与治疗前比较,治疗后对照组仅食少纳呆及肢体麻木积分明显降低,而观察组面色晦暗、食少纳呆、倦怠乏力、腰膝酸软、肢体麻木及口淡不渴积分均明显降低,且显著低于对照组（P<0.05或P<0.01）;与治疗前比较,治疗后对照组Hb、Alb含量明显降低,而观察组无显著变化,且显著高于对照组（P<0.05或P<0.01）;2组患者24 h UPQ及观察组Cys-C、BUN、Scr水平均显著降低,且观察组上述指标均明显低于对照组（P<0.01）;观察组Ccr明显升高,且明显高于对照组（P<0.05或P<0.01）;2组患者UA含量均无显著变化（P>0.05）。结论:肾衰宁胶囊可明显改善早中期CRF患者主要临床症状,阻碍CRF进展,还可调节患者肾脏血流循环,促进患者肾功能恢复,疗效显著优于常规治疗。

English Summary:

To explore the clinical efficacy and the changes of renal function indexes of Shenshuaining capsules in the treatment of patients with early and medium stage chronic renal failure （CRF）. Methods:Eighty-two cases of patients with early and medium stage CRF who were in our hospital from Mar. 2012 to Dec. 2014 were elected and randomly divided into a control group and an observation group, 41 cases for each. The control group was treated with oxygen bag aldehyde starch on the basis of conventional therapy, while observation group treated with Shenshuaining capsules on the basis of control group. Two months are one course of treatment, and 2 groups were treated for 2 courses continuously. The clinical efficacy and the main clinical symptoms integral in 2 groups were counted, and the levels of Hb, Alb, 24 h UPQ and UA were detected, the changes of renal function indexes in 2 groups before and after treatment compared. Results:The clinical efficacy of the observation group was 85.37%, which was higher than that of control group （46.34%） significantly （P<0.01）. Compared with those before treatment, the scores of lack of appetite and numb to react, numbness of limb of control group decreased significantly after treatment, while the gloomy complexion, lack of appetite and numb to react, languid, soreness and weakness of waist and knees and numbness of limb of observation group decreased significantly after treatment, which were lower than those of the control group （P<0.05 or P<0.01）. Compared with those before treatment, the levels of Hb and Alb of control group decreased significantly, while those of the observation group had no significant change and were higher than those of control group （P<0.05 or P<0.01）. The levels of 24 h UPQ and the levels of Cys-C, BUN and Scr decreased significantly, and which were lower than those of the control group （P<0.01）. The Ccr level of observation group increased significantly, which was higher than that of control group （P<0.05 or P<0.01）. The UA levels of 2 groups had no significant change （P>0.05）. Conclusion:Shenshuaining capsules can improve the main clinical symptoms obviously, impede the CRF progress. Besides it can adjust renal blood circulation and promote the recovery of renal function, and the clinical efficacy is superior to conventional therapy.

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