| 引用本文:李霞1，吴嘉婴1，周小建2.王氏保赤丸联合微生态及锌制剂治疗对小儿迁延性腹泻血清及结肠灌洗液相关指标的影响[J].世界中医药,2017,(06):. |
|
| 王氏保赤丸联合微生态及锌制剂治疗对小儿迁延性腹泻血清及结肠灌洗液相关指标的影响 |
| Effect of Wang’s Baochi Pill Combined with Probiotics and Zinc Preparation on Serum and Colonic Lavage Indicators in Treating Pediatric Persistent Diarrhea |
| 投稿时间：2017-03-29 |
| DOI：10.3969/j.issn.1673-7202.2017.06.034 |
| 中文关键词: 王氏保赤丸 微生态制剂 锌制剂 小儿迁延性腹泻 血清 结肠灌洗液 |
| English Keywords:Wang’s Baochi Pill probiotics Zinc preparations persistent diarrhea in children Serum Colonic lavage lotion |
| 基金项目: |
|
| 摘要点击次数: 960 |
| 全文下载次数: 936 |
| 中文摘要: |
| 目的:研究王氏保赤丸联合微生态及锌制剂治疗对小儿迁延性腹泻血清及结肠灌洗液相关指标的影响。方法:选取2013年3月至2016年4月上海国际医学中心收治的迁延性腹泻儿童106例,随机分成对照组（n=53）与观察组（n=53）。对照组采用基础治疗和微生态及锌制剂治疗,观察组在对照组基础上采用王氏保赤丸联合治疗,比较2组患儿治疗前后血清和结肠灌洗液中相关指标水平变化,统计临床疗效。结果:2组治疗后血清及结肠灌洗液中白介素-6（IL-6）、白介素-8（IL-8）、一氧化氮（NO）、丙二醛（MDA）水平均较治疗前下降,超氧化物歧化酶（SOD）及血锌值的水平比治疗前升高,组间差异有统计学意义（P<0.05）,且观察组比对照组更接近正常水平。观察组总有效率86.79%明显高于对照组的62.26%,2组间差异有统计学意义（P<0.01）。结论:应用王氏保赤丸联合微生态及锌制剂治疗小儿迁延性腹泻可明显降低血清及结肠灌洗液中IL-6、IL-8、NO、MDA表达水平,升高SOD水平及血锌值,降低肠道炎性反应和氧化应激,在临床上值得推广。 |
| English Summary: |
| To study the effect of Wang’s Baochi Pill combined with probiotics and zinc preparation on serum and colonic lavage indicators in treating pediatric persistent diarrhea. Methods: A total number of 106 children with persistent diarrhea in the hospital from March 2013 to April 2016 were randomly divided into control group and treatment group, with 53 cases in each group. The control group received routine treatment and probiotics and zinc preparation, while the treatment group additionally received Wang’s Baochi Pill. The levels of serum and colonic lavage indicators were compared between the two groups before and after treatment, and the clinical efficacy was analyzed. Results: The levels of IL-6, IL-8, NO and MDA in serum and colonic lavage fluid after treatment were lower than those before the treatment （P<0.05）. The levels of superoxide dismutase （SOD） and serum zinc were higher than those before the treatment and the difference in the two groups was significant （P<0.05）, and the treatment group was closer to the normal compared with the control group. The total effective rate of treatment group was 86.79% which was higher than that of control group （62.26%）, showing statistically significant difference between the two groups （P<0.01）. Conclusion: Wang’s Baochi Pill combined with probiotics and zinc preparation in the treatment of persistent diarrhea for children have better effect in serum and colonic lavage related indicators, which is worth of promotion. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
