世界中医药

目的:观察健脾益肺法治疗肌萎缩侧索硬化（ALS）患者的疗效,对治疗前后患者的肢体力量、呼吸功能以及ALS功能进行评估。方法:选取于2011年3月至2012年3月在广东省中医院神经内科门诊或病房收治的肌萎缩侧索硬化患者60例随机分为观察组和对照组,对照组仅接受基础治疗,观察组同时连用自拟的健脾益肺方,观察治疗前、治疗4周、治疗8周各组患者的ALS功能评分,MRC肌力评分、肺功能改变情况及不良反应,并进行随访。结果:治疗前后2组患者MRC肌力评分、肺功能指标,以及ALS功能量表得分均有降低,但观察组患者给药前后的ALS功能量表和MRC肌力评分差异无统计学意义（P>0.05）,与对照组比较,给药8周后观察组的MRC肌力评分及ALS功能量表得分差异均有统计学意义（P<0.05）,2组不良反应差异无统计学意义（P>0.05）。结论:健脾益肺法治疗ALS有效,能在一定程度上使患者运动及呼吸功能保持稳定,延缓疾病进展,有改善疾病预后的趋势。

English Summary:

To observe the effect of spleen-invigorating and lung-replenishing therapy to treat patients with amyotrophic lateral sclerosis （ALS） and to assess changes in physical strength, respiratory function and ALS function. Methods: Sixty ALS patients were randomly divided into two groups. Patients in the treatment group were administrated with self-made spleen-invigorating and lung-replenishing decoction for 8 weeks, while patients in the observation group were treated with conventional medication. ALS function score, MRC muscle strength score, respiratory changes and advert reactions were observed before treatment, after 4-week and 8-week treatment. A follow-up observation was also conducted then. Results: The ALS function score, MRC muscle strength score of patients in the treatment group did not show statistically significant difference before and after the treatment （P>0.05）. Compared with the observation group, the difference of MRC score and ALS score were statistically significant （P<0.05）. Conclusion: Spleen-invigorating and lung-replenishing therapy for the treatment of ALS is effective and may make ALS patients’ motor and respiratory function work stably, to some extent, prolong disease progression and improve the prognosis of the disease.

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