| 引用本文:邱敏，李晓清，邹文娟，孙科.护脉散不同给药方式对长春瑞滨致静脉炎小鼠疗效观察[J].世界中医药,2017,(10):. |
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| 护脉散不同给药方式对长春瑞滨致静脉炎小鼠疗效观察 |
| Efficacy Observation：Different Administration of Humai Powder on Vinorelbine Induced Phlebitis Mice |
| 投稿时间：2016-07-15 |
| DOI：10.3969/j.issn.1673-7202.2017.10.040 |
| 中文关键词: 静脉炎 长春瑞滨 护脉散 病理组织评分 |
| English Keywords:Phlebitis Vinorelbine Humai Powder Histopathological score |
| 基金项目:重庆市卫计委中医药科技项目（ZY201402041)；国家中医药管理局全国名老中医传承工作室建设项目［国中医药人教发〔2013〕47号］ |
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| 中文摘要: |
| 目的：观察预防性和治疗性应用护脉散对长春瑞滨致化疗性静脉炎小鼠的疗效，评价其有效性。方法：长春瑞滨尾静脉注射致小鼠静脉炎模型。分别采用预防和治疗给药2种方式，观察护脉散对给药小鼠鼠尾肿胀度、病理组织评分，并以多磺酸粘多糖乳膏为阳性对照。结果：与模型组和对照组比较，护脉散能明显减轻长春瑞滨致静脉炎小鼠鼠尾肿胀度（P<0.05），改善静脉炎鼠尾病理组织评分（P<0.01）。结论：护脉散能有效预防和治疗长春瑞滨致化疗性静脉炎，疗效优于多磺酸粘多糖乳膏。 |
| English Summary: |
| To Observe efficacy of prophylactic and therapeutic applications of Humai powder on vinorelbine induced phlebitis mice, evaluating of its effectiveness. Methods:Vinorelbine was injected intravenously on models of phlebitis. Prevention and treatment of administration were respectively used, and tails swelling condition and pathological score were observed after Humai Powder administered mouse, MPS cream as a positive control. Results:Comparing the model group and the control group, Humai powder can significantly reduce tails swelling in vinorelbine induced phlebitis mice(P<0.05), and improve tail vein inflammation pathological score (P<0.01). Conclusion:Humai powder is effective on prevention and treatment of vinorelbine induced phlebitis, stronger than MPS cream. |
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