To Observe efficacy of prophylactic and therapeutic applications of Humai powder on vinorelbine induced phlebitis mice, evaluating of its effectiveness. Methods:Vinorelbine was injected intravenously on models of phlebitis. Prevention and treatment of administration were respectively used, and tails swelling condition and pathological score were observed after Humai Powder administered mouse, MPS cream as a positive control. Results:Comparing the model group and the control group, Humai powder can significantly reduce tails swelling in vinorelbine induced phlebitis mice(P<0.05), and improve tail vein inflammation pathological score (P<0.01). Conclusion:Humai powder is effective on prevention and treatment of vinorelbine induced phlebitis, stronger than MPS cream.