| To investigate the effects of Huangqi Injection on intestinal barrier function and micro inflammatory state in acute pancreatitis.Methods:A total of 94 patients with acute pancreatitis admitted to our hospital from May 2016 to May 2017 were randomly divided into the observation group (47 cases) and the control group (47 cases).The control group was treated with conventional western medicine, and the observation group was treated with Huangqi Injection on the basis of the control group.The two groups were treated for 10 d.The therapeutic effects, the improvement of gastrointestinal function and the changes of intestinal barrier function and inflammatory factors before and after treatment were compared between the two groups.Results:The total effective rate of the observation group (93.62%) was higher than that of the control group (72.34%) (P<0.05).The recovery time of bowel sound, the disappearing time of abdominal distention, abdominal pain disappeared faster than that of control group (P<0.05).DAO, D-lactic acid and endotoxin levels decreased in two groups after treatment (observation group:t=13.8381, 23.3904, 21.2287, the control group:t=6.1162, 10.2345, 10.6497, P<0.05); DAO, D-lactic acid and endotoxin levels after treatment in the observation group were lower than the control group (t=9.4356, 14.5599, 13.4744, P<0.05).Interleukin-6 and high sensitive C reactive protein level and tumor necrosis factor alpha decreased of two groups after treatment (observation group:t=11.2854, 28.4604, 20.4710, the control group:t=4.9671, 11.3182, 7.1438, P<0.05); interleukin-6 and high sensitive C reactive protein and tumor necrosis factor alpha level in the observation group after treatment were lower than the control group (t=7.6929, 17.3327, 14.8149, P<0.055).Conclusion:Astragalus injection is effective in the treatment of acute pancreatitis, and can improve the intestinal barrier function and micro inflammatory state in patients with acute pancreatitis, and has important research value. |
