| 引用本文:钟晓莉，龙苗，贾坤林.丹参多酚酸盐联合百令胶囊对老年急性加重期慢性阻塞性肺疾病患者的疗效及对凝血指标和生命质量的影响[J].世界中医药,2018,(04):. |
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| 丹参多酚酸盐联合百令胶囊对老年急性加重期慢性阻塞性肺疾病患者的疗效及对凝血指标和生命质量的影响 |
| Effect of Salvianolate Combined with Corbrin Capsule on COPD in Elderly Patients with Acute Exacerbation and its Effect on Blood Coagulation and Quality of Life |
| 投稿时间：2017-09-28 |
| DOI：10.3969/j.issn.1673-7202.2018.04.013 |
| 中文关键词: 丹参多酚酸盐 百令胶囊 急性加重期慢性阻塞性肺疾病 疗效 D-二聚体 凝血酶原时间 凝血酶时间 生命质量 |
| English Keywords:Salvianolate Corbrin capsule Acute exacerbation of COPD Efficacy D-dimer Prothrombin time Thrombin time Quality of life |
| 基金项目:四川省卫生厅项目（130493） |
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| 中文摘要: |
| 目的：探讨丹参多酚酸盐联合百令胶囊对老年急性加重期慢性阻塞性肺疾病（COPD）患者的疗效及对凝血指标和生命质量的影响。方法：选取2014年1月至2016年12月简阳市人民医院收治的老年急性加重期COPD患者122例，按照随机数字表法分为观察组与对照组，每组61例。2组采用常规治疗，对照组给予百令胶囊，观察组在对照组基础上给予丹参多酚酸盐治疗。2组疗程均为10 d。比较2组治疗疗效，治疗前后主要症状评分、凝血指标及生命质量变化。结果：观察组治疗总有效率（91.80%）高于对照组（75.41%）（P<0.05）；2组治疗后咳嗽、气喘、咯痰评分降低（P<0.05）；观察组治疗后咳嗽、气喘、咯痰评分低于对照组（P<0.05）；2组治疗后D-二聚体降低（P<0.05）；观察组治疗后D-二聚体低于对照组（P<0.05）；而2组治疗前后PT、TT比较差异均无统计学意义（P>0.05）；2组治疗后CAT量表评分降低（P<0.05）；观察组治疗后CAT量表评分低于对照组（P<0.05）。结论：丹参多酚酸盐联合百令胶囊对老年急性加重期COPD患者疗效明显，且可降低患者凝血指标D-二聚体变化，改善患者生命质量。 |
| English Summary: |
| To investigate the effect of salvianolate combined with corbrin capsule on the elderly patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) and its effect on blood coagulation and quality of life.Methods:A total of 122 patients with acute exacerbation of COPD in our hospital from January 2014 to December 2016 were randomly divided into observation group (n=61) and control group (n=61).The two groups were treated with conventional treatment.The control group was treated with corbrin capsule，and the observation group was treated with salvianolate on the basis of the control group.The two groups were treated for 10 d.The therapeutic effects of two groups were compared before and after treatment，and the main symptom score，blood coagulation index and quality of life were compared before and after treatment.Results:The total efficiency of the observation group (91.80%) was higher than the control group (75.41%) (P<0.05); cough，asthma，expectoration score decreased in two groups after treatment (P<0.05); after treatment，cough，asthma，expectoration score of the observation group was lower than the control group (P<0.05); D-dimer decreased in two groups after treatment (P<0.05); D-dimer of the patients in the observation group was lower than the control group (P<0.05); and the difference in PT and TT of two groups before and after treatment was not statistically significant (P>0.05); CAT score of two groups after treatment decreased (P<0.05); after treatment，CAT score of the observation group was lower than the control group (P<0.05).Conclusion:Salvianolate combined with corbrin capsule has significant curative effect on elderly patients with acute exacerbation COPD，and can reduce the coagulation in D-dimer changes，improve the quality of life of patients，with important research significance. |
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