| 引用本文:冯勇，何成伟，李彬，谭冬梅，董伟琼.清胰汤配合针灸治疗肝郁气滞型急性重症胰腺炎患者的疗效及对血清炎性因子的影响[J].世界中医药,2018,(04):. |
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| 清胰汤配合针灸治疗肝郁气滞型急性重症胰腺炎患者的疗效及对血清炎性因子的影响 |
| Efficacy of Qingyi Decoction Combined with Acupuncture on Severe Acute Pancreatitis (SAP) with Liver Depression and Qi Stagnation Syndrome and Effects on Serum Inflammatory Factors |
| 投稿时间：2017-10-19 |
| DOI：10.3969/j.issn.1673-7202.2018.04.018 |
| 中文关键词: 清胰汤 肝郁气滞型 急性重症胰腺炎 TNF-α IL-6 IL-8 炎性因子 疗效 |
| English Keywords:Qingyi decoction Liver depression and qi stagnation syndrome Severe acute pancreatitis TNF-α IL-6 IL-8 Inflammatory factors Curative effect |
| 基金项目:四川省科技厅项目（2015JQ0058） |
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| 中文摘要: |
| 目的：观察清胰汤配合针灸治疗肝郁气滞型急性重症胰腺炎的临床疗效，同时分析对部分血清炎性因子的影响。方法：选取2014年7月至2016年7月收治的肝郁气滞型急性重症胰腺炎患者72例，随机分为对照组和观察组各36例。对照组患者接受西医治疗方案，主要包含禁食、胃肠减压，基础支持，抑酸、抗感染等治疗；观察组在此基础上增加清胰汤及针灸治疗。比较2组患者临床疗效，血淀粉酶、肝肾功能以及血清炎性反应指标等。结果：观察组临床疗效优于对照组(P<0.05）。治疗后2组血淀粉酶和肝肾功能指标低于治疗前（P<0.05）；且观察组降低程度大于对照组（P<0.05）。治疗前2组患者的血清TNF-α、IL-6、IL-8水平差异无统计学意义（P>0.05），治疗后，观察组血清TNF-α、IL-6、IL-8值均低于对照组，差异有统计学意义（P<0.05）。结论：清胰汤配合针灸能有效治疗肝郁气滞型急性重症胰腺炎，其作用机制可能与降低TNF-α、IL-6、IL-8等血清炎性因子表达有关。 |
| English Summary: |
| To observe the clinical curative effect of Qingyi decoction on severe acute pancreatitis (SAP)，at the same time to analyze the influence on the hematology inflammatory indexes.Methods:A total of 72 cases of SAP patient in our hospital were included in the study，and randomly divided into the control group and the test group，with 35 cases in each group.The control group accepted western medicine treatment，including fasting，gastrointestinal decompression，basic support，acid suppression and anti-infection.Besides，the test group was treated combined with Qingyi decoction and acupuncture on the basis of the control group，The efficacy，clinical syndrome integrals，AMY，ALT，Cr levels，TNF-α，IL-6 and IL-8 changes in serum concentration levels of two groups before and after treatment were compared.Results:1) Clinical efficacy of testt group was more significant than control group (P<0.05).2) The levels of AMY，ALT，Cr levels of test group declined after treatment (P<0.05)，the downward trend of the test group was more significant when compared with the control group，and the statistical differences were significant (P<0.05).3) Detected by ELISA test，TNF-α，IL-6 and IL-8 levels of the two groups have no statistically significant difference before treatment (P>0.05)，and decreased after treatment with significant differences (P<0.05).Conclusion:Qingyi decoction combined with acupuncture can effectively treat SAP patient with liver depression and qi stagnation，whose mechanism may be related to the reduction of inflammation level. |
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