| 引用本文:孙阿梅1，刘长云1，刘汉蓉1，汪正芳2.抗衰汤联合激素补充疗法治疗卵巢早衰对妇女内分泌及卵巢功能的影响[J].世界中医药,2018,(04):. |
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| 抗衰汤联合激素补充疗法治疗卵巢早衰对妇女内分泌及卵巢功能的影响 |
| Effects of Kangshuai Decoction Combined with Hormone Replacement Therapy on the Endocrine and Ovarian Function in the Treatment of Women with Premature Ovarian Failure |
| 投稿时间：2017-12-26 |
| DOI：10.3969/j.issn.1673-7202.2018.04.024 |
| 中文关键词: 卵巢早衰 抗衰汤 激素补充疗法 内分泌 卵巢功能 |
| English Keywords:Premature ovarian failure Kangshuai Decoction Hormone replacement therapy Endocrine Ovarian function |
| 基金项目:北京市中医药科技发展资金项目（JJ2014-35） |
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| 中文摘要: |
| 目的：探讨抗衰汤联合激素补充疗法治疗卵巢早衰（Premature Ovarian Failure，POF）对妇女内分泌及卵巢功能的影响。方法：选取2014年1月至2016年10月湖北省应城市人民医院收治的POF患者500例，随机分为观察组与对照组，每组250例。对照组采用激素补充疗法，观察组在对照组的基础上给予抗衰汤治疗，21 d为1个疗程，2组均连续治疗3个疗程。统计2组临床疗效；比较治疗前后2组内分泌激素水平、卵巢功能指标；记录治疗期间2组不良反应发生率。结果：治疗后观察组总有效率为92.40%，显著高于对照组的80.80%，差异有统计学意义（P<0.05）；治疗后2组血清E2水平较治疗前显著升高，且观察组显著高于对照组，差异有统计学意义（P<0.01）；治疗后2组血清LH、FSH水平较治疗前显著下降，且观察组显著低于对照组，差异有统计学意义（P<0.05或P<0.01）；与治疗前比较，治疗后2组OV增大、FN及子宫内膜厚度增大，PSV加快，且观察组均显著优于对照组，差异有统计学意义（P<0.01）；治疗期间观察组不良反应发生率（22.00%）显著低于对照组（38.00%），差异有统计学意义（P<0.05）。结论：抗衰汤联合激素补充疗法可有效调节POF妇女内分泌激素水平，显著改善其卵巢功能，临床疗效优于单纯激素补充治疗。 |
| English Summary: |
| To explore the effects of Kangshuai Decoction combined with hormone replacement therapy on the endocrine and ovarian function in the treatment of women with premature ovarian failure (POF). Methods:A total of 500 cases of POF patients treated in our hospital from January 2014 to October 2016 were selected and randomly divided into observation group and control group, with 250 cases in each group. Control group was treated with hormone replacement therapy, and the observation group was treated with Kangshuai Decotion on the basic of control group. 21 days were for a treatment course. Both groups were treated for 3 courses continuously. The clinical effects of 2 groups were statisticsed, and the endocrine hormone levels, ovarian function of 2 groups were compared before and after treatment; the incidence of adverse reactions of 2 groups in the treatment were recorded. Results:The total effective rate of observation group after treatment was 92.40%, which was significantly higher than the .80.80% of control group (P<0.05); the levels of serum E2 in 2 groups after treatment were significantly higher than before treatment, and observation group was significantly higher than control group (P<0.01); the levels of serum LH and FSH in 2 groups after treatment were significantly lower than before treatment, and observation group was significantly lower than control group (P<0.05 or P<0.01); compared with control group, the OV, FN, endometrium thickness of 2 groups increased, and the PSV of 2 groups quickened after treatment. The observation group was significantly better than control group (P<0.01); the incidence of adverse reactions in the treatment group (22.00%) was significantly lower than that of the control group (3.8.00%) (P<0.05). Conclusion:Kangshuai Decoction combined with hormone replacement therapy in the treatment of POF can effectively regulate the level of endocrine hormones in women, and significantly improve their ovarian function. The clinical efficacy is superior to simple hormone replacement therapy. |
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