| 引用本文:吕振选1，田国防1，李春青1，吕朝凤1，张清琴2.化疗对晚期非小细胞肺腺癌患者中医证候的影响[J].世界中医药,2018,(04):. |
|
| 化疗对晚期非小细胞肺腺癌患者中医证候的影响 |
| Effect of Chemotherapy on Traditional Chinese Medicine Syndromes in Patients with Advanced Non-small Cell Lung Adenocarcinoma |
| 投稿时间：2018-02-12 |
| DOI：10.3969/j.issn.1673-7202.2018.04.028 |
| 中文关键词: 培美曲塞 顺铂 化疗 原发性晚期非小细胞肺腺癌 中医证候 |
| English Keywords:Pemetrexed Cisplatin Chemotherapy Primary advanced non-small cell lung adenocarcinoma TCM syndrome |
| 基金项目:河南省医学科技攻关计划(2011020091) |
|
| 摘要点击次数: 943 |
| 全文下载次数: 818 |
| 中文摘要: |
| 目的：探讨培美曲塞联合顺铂（PP）化疗方案对原发性晚期非小细胞肺腺癌患者中医证候的影响。方法：选取2015年1月至2017年1月新乡市中心医院肿瘤内科收治的经病理学检查明确确诊的晚期原发性非小细胞肺腺癌患者112例，进行PP化疗方案治疗，于化疗前8 d和化疗后第8天、16天分别观察患者的中医证型、舌象以及脉象。结果：化疗后第8天脾虚痰湿证患者（12.50%）明显少于化疗前8 d脾虚痰湿证患者（40.08%）,差异有统计学意义（P<0.05）；化疗后第8天气阴两虚证（27.68%）和气滞血瘀证（25.00%）患者明显多于化疗前8 d气阴两虚证（9.82%）和气滞血瘀证（7.14%）患者（P<0.05）；化疗后8 d淡红舌（25.89%）、腻舌（11.61%）患者明显少于化疗前第8天淡红舌（36.61%）、腻舌（25.00%）患者（P<0.05）；化疗后8 d红舌（33.93%）、紫暗舌（19.64%）、光剥苔（44.64%）患者明显多于化疗前第8天红舌（22.32%）、紫暗舌（5.36%）、光剥苔（21.43%）患者；化疗后8 d细脉（28.57%）、滑脉（9.82%）患者患者明显少于化疗前第8天细脉（37.50%）、滑脉（25.89%）患者患者，差异有统计学意义（P<0.05）；化疗后8 d细数脉（22.32%）、弦脉（25.00%）患者明显多于化疗前第8天细数脉（9.82%）、弦脉（7.14%）患者，差异有统计学意义（P<0.05）。结论：原发性晚期非小细胞肺腺癌患者行PP方案前后中医证候变化有规律可循，化疗后气阴两虚证、气滞血瘀证，可在化疗前增加相应中医药干预治疗。 |
| English Summary: |
| To investigate the effect of pemetrexed combined with cisplatin (PP) chemotherapy on TCM syndrome of patients with advanced non-small cell lung adenocarcinoma.Methods:A total of 112 patients with advanced primary non-small cell lung adenocarcinoma who were confirmed by pathology in our hospital from January 2015 to January 2017 were treated with PP chemotherapy.The TCM syndromes，tongue images and pulse conditions were observed 8 days before chemotherapy and 8 and 16 days after chemotherapy respectively.Results:The number of patients with spleen deficiency and phlegm dampness syndrome (12.50%) on the 8th day after chemotherapy was significantly smaller than those with spleen deficiency and phlegm dampness syndrome (40.08%) on the 8th day before chemotherapy (P<0.05); On the 8th day after chemotherapy，the number of patients with qi and yin deficiency ( 27.68 % ) and stagnation of qi and blood stasis syndrome (25.00%) was significantly larger than those with qi and yin deficiency (9.82%) and stagnation of qi and blood stasis syndrome (7.14%) before chemotherapy (P<0.05 ).The number of patients with pale red tongue (25.89%) and greasy tongue (11.61%) on the 8th day after chemotherapy was significantly smaller than those with pale red tongue (36.61%) and greasy tongue (25.00%) on the 8th day before chemotherapy (P<0.05).The number of patients with red tongue (33.93%)，dark purple tongue (19.64%)，and light peeled tongue (44.64%) was significantly larger than those with red tongue (22.32%)，dark purple tongue (5.36 %) and light peeled tongue (21.43%) on the 8th day after chemotherapy.The number of patients with fine pulse (28.57%) and slippery pulse (9.82%) on the 8th day after chemotherapy was significantly smaller than those with fine pulse (37.50%) and slippery pulse (25.89%) on the 8th day before chemotherapy (P<0.05).The number of patients with fine and rapid pulse (22.32%) and stringed pulse (25.00%) on the 8th day after chemotherapy was significantly larger than those with fine and rapid pulse (9.82%) and stringed pulse (7.14%) on the 8th day before chemotherapy (P<0.05 ).Conclusion:There are regular changes of TCM syndromes before and after PP regimen in patients with advanced non-small cell lung adenocarcinoma.For patients with PP regimen chemotherapy，the methods of invigorating qi，nourishing yin，regulating qi and removing blood stasis can be used for early intervention. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
