| 引用本文:王彩虹1，时君2.蒲苓盆炎康颗粒联合抗生素治疗慢性盆腔炎的疗效评价[J].世界中医药,2018,(06):. |
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| 蒲苓盆炎康颗粒联合抗生素治疗慢性盆腔炎的疗效评价 |
| Evaluation on the Efficacy of Puling Penyankang Granule Combined with Antibiotics in the Treatment of Chronic Pelvic Inflammatory Disease |
| 投稿时间：2018-04-13 |
| DOI：10.3969/j.issn.1673-7202.2018.06.043 |
| 中文关键词: 蒲苓盆炎康颗粒 抗生素 慢性盆腔炎 |
| English Keywords:Puling Penyankang Granule Antibiotic Chronic pelvic inflammatory |
| 基金项目:上海市卫计委项目（20134Y072）——验方“盆炎汤”对慢性盆腔炎大鼠细胞因子及T细胞亚群的影响 |
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| 中文摘要: |
| 目的：探讨蒲苓盆炎康颗粒联合抗生素治疗慢性盆腔炎的临床疗效。方法：选取2014年3月至2015年10月日照市妇幼保健计划生育服务中心收治的慢性盆腔炎患者118例。慢性盆腔炎患者按治疗方案不同分为对照组(n=58)与观察组(n=60)，对照组行常规抗生素治疗，观察组行蒲苓盆炎康颗粒联合抗生素治疗，观察2组的临床效果、炎性因子水平变化、血液流变学指标变化及停药后复发率。计量资料采用t检验进行2组间比较，计数资料采用Chi2检验进行2组间比较。结果：观察组总有效率明显高于对照组(77.59% vs.93.33%，P<0.05)；治疗后2组TNF-α水平均降低，IL-2水平均升高，且观察组改善更为明显，差异具有统计学意(P<0.05)；治疗后观察组血液流变学指标明显改善(P<0.05)；观察组停药3、6、12个月的复发率明显低于对照组(P<0.05)，治疗期间2组均未见明显的不良反应。结论：蒲苓盆炎康颗粒联合抗生素能够提高临床疗效，发挥较好的抗炎、改善组织微循环作用。 |
| English Summary: |
| To explore the efficacy of Puling Penyankang Granule combined with antibiotics in the treatment of chronic pelvic inflammatory disease.Methods:A total of 118 patients with chronic pelvic inflammatory disease were divided into control group and treatment group according to different treatments.The general antibiotics were given in the control group,and Puling Penyankang Granule combined with antibiotics was given in the treatment group.The clinical efficacy,changes of inflammatory factors,changes of hemorheological targets and recurrence rate after drug withdrawal were compared between two groups.For sub-group comparisons (treatment group and control group),t-test was utilized for continuous variables,while Fisher's exact test and Chi-square test were utilized for categorical variables.Results:The total effective rate in the treatment group was significant higher than the control group (77.59% vs.93.33%,P<0.05); The level of TNF-α were both decreased in the two groups,while the level of IL-2 were both increased.Changes were more significant in the treatment group with statistical difference (P<0.05).Hemorheological targets were improved significantly in the treatment group (P<0.05).The recurrence after drug withdrawal in 3,6 and 12 months in the treatment group were lower than the control group with statistical difference (P<0.05).Besides,significant side effects were not found in both treatment group and control group.Conclusion:The treatment of Puling Penyankang Granule combined with antibiotics improves clinical efficacy,and plays a better role in the anti-inflammatory and improving the microcirculation. |
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