| 引用本文:于海娜1，刘永丹2，裴晓蕊1.银杏达莫配合依达拉奉治疗急性脑梗死的应激指标和神经功能变化研究[J].世界中医药,2019,(02):. |
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| 银杏达莫配合依达拉奉治疗急性脑梗死的应激指标和神经功能变化研究 |
| Study on the Effects of Ginkgo Combined with Edaravone on Stress Indexes and Changes of Neurological Function in Treatment of Acute Cerebral Infarction |
| 投稿时间：2018-09-30 |
| DOI：10.3969/j.issn.1673-7202.2019.02.030 |
| 中文关键词: 银杏达莫 依达拉奉 急性脑梗死 应激指标 神经功能 神经递质 应激反应 NIHSS评分 |
| English Keywords:Ginkgo Edaravone Acute cerebral infarction Stress index Neurofunction Neurotransmitter Stress response NIHSS score |
| 基金项目:国家自然科学基金项目（81400988）——MicroRNA-155调节CD4+T细胞分化并与多发性硬化发病机制相关 |
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| 中文摘要: |
| 目的:分析银杏达莫配合依达拉奉应用于急性脑梗死,对患者神经功能与应激指标的影响。方法:选取2016年4月至2017年4月朝阳市中心医院收治的急性脑梗死患者112例,按照治疗方案的不同分为对照组(n=54)和观察组(n=58)。对照组予以依达拉奉治疗,观察组予以依达拉奉+银杏达莫治疗,于治疗前1 d、治疗14 d后检测2组神经递质指标、应激指标、神经功能NIHSS评分,比较2组治疗14 d内的疗效。结果:1)观察组在治疗后AOPP(75.12±3.74)μmol/L、IL-6(71.62±5.01)pg/mL、ox-LDL(85.80±5.26)U/mL、CRP(9.18±0.55)mg/L、MDA(3.08±0.56)nmol/mL、IL-10(22.13±1.62)μg/L显著低于对照组,GSH-Px(39.18±6.28)mg/mL、SOD(162.54±13.15)U/mL显著高于对照组(P<0.05);(2)观察组在治疗后VAP(8.12±1.74)ng/L、NPY(170.52±6.15)μg/L、NSE(12.13±1.62)μg/L、Glu(71.62±4.01)μmol/L显著低于对照组,NGF(89.18±3.28)pg/mL、GABA(9.08±0.86)μmol/L、NTF(5.80±0.76)ng/mL、NAA(429.18±17.55)mmol/L显著高于对照组(P<0.05);3)观察组在治疗后NIHSS评分总分(11.50±1.62)分显著低于对照组(18.00±1.78)分(P<0.05);4)观察组总有效率(96.55%)显著高于对照组(87.04%)(P<0.05)。结论:对于急性脑梗死,可采取银杏达莫辅助依达拉奉治疗,比较单纯应用依达拉奉,能够有效调节患者应激反应、神经递质表达,提高患者神经功能,疗效较好。 |
| English Summary: |
| To analyze the effects of ginkgo combined with edaravone on neurological function and stress index for the patients with acute cerebral infarction. Methods:From April 2016 to April 2017, a total of 112 patients with acute cerebral infarction in Chaoyang Central Hospital were selected. According to the different scheme, they were divided into two groups. The control group (n=54) was treated with edaravone and the observation group (n=58) was given ginkgo combined with edaravone. The neurotransmitter index, stress index and NIHSS score of nerve function were detected for 1 day before treatment and 14 days after treatment. The effects were compared between two groups. Results:1) In the observation group after the treatment, AOPP (75.12±3.74) μmol/L, IL-6 (71.62±5.01) pg/mL, ox-LDL (85.80±5.26) U/mL, CRP (9.18±0.55) mg/L, MDA (3.08±0.56) nmol/mL, IL-10 (22.13±1.62) μg/L were significantly lower than those in the control group. GSH-Px (39.18±6.28) mg/mL, SOD (162.54±13.15) U/mL were significantly higher than that in the control group (P<0.05). 2) In the observation group after the treatment, VAP (8.12±1.74) ng/L, NPY (170.52±6.15) μg/L, NSE (12.13±1.62) μg/L, Glu (71.62±4.01) μmol/L were significant lower than those in the control group. NGF (89.18±3.28) pg/mL, GABA (9.08±0.86) μmol/L, NTF (5.80±0.76) ng/mL, NAA (429.18±17.55) mmol/L were significant higher than those in the control group (P<0.05). 3) In the observation group after the treatment, the total NIHSS score (11.50±1.62) was significantly lower than that in the control group (18.00±1.78) (P<0.05). 4) The total effective rate in the observation group was 96.55%. It was significantly higher than that in the control group (87.04%) (P<0.05). Conclusion:For the treatment of acute cerebral infarction, ginkgo can effectively regulate the stress response, neurotransmitter expression and improve the neurological function of the patients compared with edaravone alone. |
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