| 引用本文:吕鹏，赵欢，李蕊白，潘一鸣，韩丽珍，张雅月，侯丽.围诱导化疗期联合康莱特注射液对老年急性髓系白血病消化道不良反应及生命质量的影响[J].世界中医药,2019,(02):. |
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| 围诱导化疗期联合康莱特注射液对老年急性髓系白血病消化道不良反应及生命质量的影响 |
| Effects of Kanglaite Injection in Period of Peri-induction Chemotherapy on Gastrointestinal Reactions and Life Quality of the Aged with Acute Myeloid Leukemia (M3 excluded) |
| 投稿时间：2017-07-16 |
| DOI：10.3969/j.issn.1673-7202.2019.02.035 |
| 中文关键词: 老年人 急性髓系白血病 康莱特注射液 生命质量 不良反应 化疗 消化道 回顾性临床研究 |
| English Keywords:Elderly patients Acute myeloid leukemia Kanglaite Injection Life quality Toxic reaction Chemotherapy Digestive tract Retrospective clinical study |
| 基金项目:北京市科学技术委员会G20工程支撑保障“十病十药”项目（Z151100003815027）；北京中医药大学2016年度基本科研业务在读研究生项目（2016-JYB-XS153）；北京中医药大学2016年度中青年教师项目(2016-JYB-JSMS022) |
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| 中文摘要: |
| 目的：评价老年急性髓系白血病（AML）（非M3）围诱导化疗期联合应用康莱特注射液对消化道不良反应及生命质量的影响。方法：选取2009年1月至2016年1月东直门医院老年AML住院患者140例，根据住院期间有无联合应用康莱特注射液分为联合观察组及单纯观察组。共检索出符合纳排标准的老年AML（非M3）患者55例。单纯观察组23例，其中初诊初治8例，复发难治15例；联合观察组32例，其中初诊初治10例，复发难治22例，差异无统计学意义(P>0.05)。结果：2组病例Ⅰ、Ⅱ度口腔反应及口腔不良反应发生率分别为21.7%、17.4%、39.1%（单纯观察组），0%、3.1%、3.1%（联合观察组），单纯观察组Ⅰ、Ⅱ度口腔反应及口腔不良反应发生率均明显高于联合观察组（P=0.001＜0.01）；在胃肠道反应方面，单纯观察组发生Ⅱ、Ⅲ度反应及不良反应发生率分别为30.5%、13%、43.5%，高于联合观察组的12.5%、9.4%、34.4%，在减少胃肠道反应方面表现出一定优势，但差异无统计学意义（P>0.05）；1个疗程后KPS评分在改善、稳定及有效率分别为12.5%、75%、87.5%（联合观察组）、0%、65.2%、65.2%（单纯观察组），联合观察组优于单纯观察组（P<0.05）。结论：老年AML（非M3）患者围诱导化疗期联合应用康莱特注射液能降低患者口腔毒性反应分度及发生率，具有降低胃肠道不良反应趋势,主要体现在复发难治患者；改善患者1个诱导疗程后的生命质量。 |
| English Summary: |
| To evaluate gastrointestinal reactions and changes of life quality in the aged patients with acute myeloid leukemia (AML) (M3 excluded) undergoing induction chemotherapy combined with Kanglaite Injection.Methods:A retrospective clinical study was performed.A total of 140 aged patients with AML admitted to Dongzhimen Hospital from January 2009 to January 2016 were screened and divided into two groups：those who received Kanglaite Injections were categorized into the combined treatment group，while those who did not were placed in the simple treatment group.Results:A total of 55 aged patients with AML (M3 excluded) were eligible for inclusion according to clinical study criteria，among which 23 were placed in the simple treatment group，and 32 were placed in the Kanglaite Injection (combined treatment) group.In the combined treatment group，10 were diagnosed as AML for the first time，while 22 were relapsed cases; in the simple treatment group，8 were diagnosed as AML for the first time，while 15 were relapsed cases.The differences in distribution were not statistically significant (P>0.05).Occurrence of grade I oral reaction，grade II oral reaction，and oral adverse reaction was 21.7%，17.4%，and 39.1% respectively in the simple treatment group，which was significantly higher than 0%，3.1%，and 3.1% in the combined treatment group (P=0.001<0.01).In regards to gastrointestinal reactions，occurrence of grade II reaction，grade III reaction，and adverse reaction was 30.5%，13.0%，and 43.5% respectively in the simple treatment group，which was higher than 12.5%，9.4%，and 34.4% in the combined treatment group，but the results were not statistically significant (P>0.05).After one course of induction chemotherapy combined with Kanglaite Injection for elderly AML (M3 excluded) patients，the KPS scores of improving，stabilizing and effective rates were 12.5%，75.0% and 87.5% respectively in the simple treatment group，and were 0%，65.2% and 65.2% respectively in the combined treatment group.Induction chemotherapy combined with Kanglaite Injection was significantly effective in improving quality of life (P<0.05).Conclusion:The results of this study indicate that induction chemotherapy combined with Kanglaite Injection has the following effects for elderly AML (M3 excluded) patients：improving oral toxic reactions and degrees，reducing gastrointestinal reactions，especially for relapsed patients，and improving life quality after 1 course of induced chemotherapy. |
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