| 引用本文:赵耀东，徐文东.强骨胶囊联合柳氮磺吡啶治疗类风湿性关节炎并发骨质疏松的临床效果[J].世界中医药,2019,(02):. |
|
| 强骨胶囊联合柳氮磺吡啶治疗类风湿性关节炎并发骨质疏松的临床效果 |
| Clinical Observation on Qianggu Capsule Combined with Sulfasalazine on Bone Metabolism in Patients with Rheumatoid Arthritis Complicated with Osteoporosis |
| 投稿时间：2018-10-29 |
| DOI：10.3969/j.issn.1673-7202.2019.02.038 |
| 中文关键词: 类风湿性关节炎 骨质疏松 强骨胶囊 骨代谢 柳氮磺吡啶 |
| English Keywords:Rheumatoid arthritis Osteoporosis Qianggu Capsule Bone metabolism Sulfasalazine |
| 基金项目:2017年度河南省医学科技攻关计划项目（201702111） |
|
| 摘要点击次数: 856 |
| 全文下载次数: 682 |
| 中文摘要: |
| 目的：探讨强骨胶囊联合柳氮磺吡啶治疗类风湿性关节炎并发骨质疏松对患者骨代谢的影响。方法：选取2015年1月至2018年1月郑州大学第五附属医院收治的类风湿性关节炎并发骨质疏松患者96例，按照随机数字表法分为对照组与观察组，每组48例。所有患者均采用常规治疗，对照组在常规治疗基础上采用柳氮磺吡治疗，观察组在对照组基础上应用强骨胶囊进行治疗，3个月为1个疗程，2组均连续治疗2个疗程。比较2组临床疗效；评估2组临床症状改善情况；检测并比较2组患者骨代谢水平。结果:治疗后，观察组与对照组的总有效率分别为62.50%、52.08%，差异无统计学意义（P>0.05）。治疗后2组关节压痛指数、关节功能指数、关节肿胀指数均较治疗前下降，2组晨僵时间均较治疗前显著缩短，且2组差异有统计学意义（P<0.05）。治疗后2组患者血钙离子水平、骨钙素（BGP）及甲状旁腺素（PTH）水平较治疗前显著升高，差异有统计学意义（P<0.05），2组红细胞沉降率（ESR）、血清骨碱性磷酸酶（BALP）、Ⅰ型胶原交联C-末端肽（CTX-Ⅰ）水平显著下降（P<0.05），且2组差异有统计学意义（P<0.05）。治疗后2组患者腰椎及Ward's三角区骨密度（BMD）显著升高，差异有统计学意义（P<0.05），且2组差异有统计学意义（P<0.05）。结论:强骨胶囊联合柳氮磺吡啶治疗类风湿性关节炎并发骨质疏松可有效缓解患者临床症状，改善其骨代谢，增加BMD，有利于患者康复。 |
| English Summary: |
| To explore the effects of Qianggu Capsule combined with sulfasalazine on bone metabolism in patients with rheumatoid arthritis complicated with osteoporosis. Methods:A total of 96 patients with rheumatoid arthritis complicated with osteoporosis in The Fifth Affiliated Hospital of Zhengzhou University were selected as study objects from January 2015 to January 2018，and they were randomly divided into control group and observation group with 48 cases in each group. All patients were treated with routine therapy，the control group was treated with sulfasalazine on the basis of routine therapy，and the observation group was treated with Qianggu Capsule on the basis of the control group，3 months as a course of treatment，the 2 groups were treated continuously for 2 courses. The clinical effects of the 2 groups were compared; the clinical symptoms of the 2 groups were evaluated before and after treatment; The bone metabolism levels of the 2 groups were detected and compared before and after treatment. Results:After treatment，the total effective rates of the observation group and the control group were 62.50% and 52.08% respectively. There was no significant difference in the total effective rate between the 2 groups. (P>0.05). After treatment，the joint tenderness index，joint function index and joint swelling index of the 2 groups were lower than those before treatment，and the morning stiffness time of the 2 groups was significantly shorter than that before treatment，and there were significant differences between the 2 groups (P<0.01). After treatment，the serum calcium concentration，BGP and PTH levels of the 2 groups were significantly higher than those before treatment (P<0.01)，the levels of ESR，BALP and CTX-I in the 2 groups were significantly lower than those before treatment (P<0.01)，and there were significant differences between the 2 groups (P<0.05 or P<0.01). After treatment，the BMD levels in the lumbar spine and Ward's Triangle were significantly higher of the 2 groups (P<0.01)，and the BMD levels in the observation group were significantly higher than those in the control group (P<0.01). Conclusion:Qianggu Capsule combined with sulfasalopyridine in the treatment of rheumatoid arthritis complicated with osteoporosis can effectively relieve the clinical symptoms，improve bone metabolism，increase BMD. It's beneficial to patients' rehabilitation. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
