| 引用本文:朱远旺，毛希宏.金天格胶囊对骨质疏松骨折患者炎性反应递质表达的影响[J].世界中医药,2019,(02):. |
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| 金天格胶囊对骨质疏松骨折患者炎性反应递质表达的影响 |
| Effects of Jintiange Capsules on Expression of Inflammatory Factors in Patients with Osteoporotic Fracture |
| 投稿时间：2017-08-24 |
| DOI：10.3969/j.issn.1673-7202.2019.02.040 |
| 中文关键词: 金天格胶囊 骨质疏松 骨折 炎性反应递质 骨密度 单核细胞趋化蛋白-1 肿瘤坏死因子-α 白细胞介素 |
| English Keywords:Jintiange Capsule Osteoporosis Fracture Inflammatory factor Bone density Monocyte chemoattractant protein-1 Tumor necrosis factor-α Interleukin |
| 基金项目:云南省卫生科技计划项目(2016NS314）——脉冲射频对神经病理性痛大鼠P物质表达影响的实验研究 |
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| 中文摘要: |
| 目的：探讨金天格胶囊对骨质疏松骨折患者炎性反应递质表达的影响。方法：选取2016年1月至2016年12月昆明市延安医院收治的骨质疏松性骨折140例作为研究对象，按照入组先后顺序分为观察组与对照组，每组70例，对照组给予口服钙尔奇D3元素片，观察组给予金天格胶囊口服，疗程6个月。结果：治疗3个月后肿瘤坏死因子-α(TNF-α)、白细胞介素-1(IL-1)-1、IL-6、IL-10、IL-17及单核细胞趋化蛋白-1（MCP-1）水平观察组显著低于对照组，差异有统计学意义（P<0.05）；观察组治疗6个月后TNF-α、IL-1、IL-10、IL-17及MCP-1水平显著低于对照组，差异有统计学意义（P<0.05）；观察组治疗6个月后的L1-4骨密度高于对照组，差异有统计学意义（P<0.05）；骨质疏松后骨折患者L1-4骨密度平与TNF-α、IL-1、IL-10、IL-17及MCP-1呈负相关（P<0.05）。结论：金天格胶囊可有效提升骨质疏松骨折患者L1-4骨密度，抑制骨细胞炎性反应递质表达可能是骨密度提升的机制之一。 |
| English Summary: |
| To explore the effects of Jintiange Capsules on the expression of inflammatory factors in patients with osteoporotic fracture.Methods:A total of 140 cases of patients with osteoporotic fracture admitted to Yan'an Hospital of Kunming City from January 2016 to December 2016 were included and were divided into study group and control group according to the joining order，with 70 cases in each group.The control group was given oral calcium element tablets of Caltrate，while the study group was given Jintiange Capsules orally for 6 months.Results:The levels of TNF-α，IL-1，IL-6，IL-10，IL-17 and MCP-1 of the study group were significantly lower than those of the control group after 3 months of treatment.The levels of TNF-Α，IL-1，IL-10，IL-17 and MCP-1 of the study group were significantly lower than those of the control group after 6 months of treatment (P<0.05).The levels of L1-4 BMD of the study group was significantly higher than that of the control group at the same period (P<0.05).The level of L1-4 BMD in patients with osteoporosis showed a significant negative correlation with TNF-α，IL-1,IL-10，IL-17 and MCP-1 (P<0.05).Conclusion:Jintiange Capsules can effectively improve the bone mineral density of L1-4 bone in patients with osteoporotic fracture，and one of the mechanisms may be its effects in suppressing the expression of inflammatory factors of bone cells. |
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