| 引用本文:宋焕清，宋红，李晶晶，冯晓霞，霍志芳.四磨汤联合茵栀黄口服液对新生儿黄疸患儿胆红素水平、免疫功能及NBNA评分的影响[J].世界中医药,2019,(02):. |
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| 四磨汤联合茵栀黄口服液对新生儿黄疸患儿胆红素水平、免疫功能及NBNA评分的影响 |
| Effects of Simo Decoction Combined with Yinzhihuang Oral Liquid on Bilirubin Level，Immune Function and Neonatal Behavioral Neurological Assessment Score in Jaundice of Newborn |
| 投稿时间：2018-09-06 |
| DOI：10.3969/j.issn.1673-7202.2019.02.041 |
| 中文关键词: 四磨汤 茵栀黄口服液 新生儿黄疸 疗效 胆红素 免疫功能 NBNA评分 不良反应 |
| English Keywords:Simo decoction Yinzhihuang oral liquid Neonate jaundice Curative effect Bilirubin Immune function Neonatal behavioral neurological assessment Adverse reaction |
| 基金项目:河南省医学科技攻关计划项目（201504237） |
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| 中文摘要: |
| 目的：探讨四磨汤联合茵栀黄口服液对新生儿黄疸患儿胆红素水平、免疫功能及新生儿行为神经评估（NBNA）评分的影响。方法：选取2016年10月至2018年4月郑州大学第二附属医院收治的病理性黄疸新生儿124例，按照随机数字表法随机分为对照组和观察组，每组62例。对照组采用茵栀黄口服液治疗，观察组采用四磨汤联合茵栀黄口服液治疗。评价2组患儿的治疗效果，比较2组患儿的血清胆红素、免疫功能指标及NBNA评分变化情况。记录并比较2组患儿的不良反应发生情况。结果：观察组治疗总有效率为96.77%，明显高于对照组的85.48%（P<0.05）。治疗后2组血清胆红素水平均明显下降，且观察组明显低于对照组（P<0.05），观察组患儿血清胆红素恢复至正常所需天数明显短于对照组（P<0.05）。治疗后2组患儿CD4+、CD4+/CD8+以及IgA、IgG水平均明显升高，且观察组明显高于对照组（P<0.05）。治疗后2组患儿NBNA评分均明显升高，且观察组高于对照组（P<0.05）。2组不良反应发生率比较，差异无统计学意义（P>0.05）。结论：四磨汤联合茵栀黄口服液治疗新生儿黄疸疗效确切，可降低患儿的血清胆红素水平，提高患儿的免疫功能，并有利于患儿的神经发育，值得临床推广。 |
| English Summary: |
| To explore the effects of Simo decoction combined with Yinzhihuang oral liquid on bilirubin level，immune function and neonatal behavioral neurological assessment (NBNA) score in jaundice of newborn.Methods:A total of 124 cases of jaundice of newborn who were treated in the Second Affiliated Hospital of Zhengzhou University from October 2016 to April 2018 were selected.They were divided into control group and observation group according to random number table method，with 62 cases in each group.The control group was treated with Yinzhihuang oral liquid，and the observation group was treated with Simo decoction combined with Yinzhihuang oral liquid.The changes of serum bilirubin，immune function and NBNA score were compared between the two groups.The adverse reactions of the two groups were recorded and compared.Results:The total effective rate of the observation group was 96.77%，which was significantly higher than 85.48% in the control group (P<0.05).After the treatment，the serum bilirubin levels of the two groups were significantly decreased，and the observation group was significantly lower than that of the control group (P<0.05).Meanwhile，the days of the serum bilirubin returned to normal in the observation group were significantly shorter than those in the control group (P<0.05).After the treatment，the levels of cluster of differentiation 4+ (CD4+) and CD4+/CD8+ and Immune Gloulin A (IgA)，IgG in the two groups were significantly increased.However，the observation group were significantly higher than those in the control group (P<0.05).After the treatment，the NBNA scores of the two groups were significantly increased，and the observation group was significantly higher than that of the control group (P<0.05).There was no significant difference in adverse reactions between the two groups (P>0.05).Conclusion:Simo decoction combined with Yinzhihuang oral liquid is effective in the treatment of jaundice of newborn.It can rapidly reduce serum bilirubin level in children，improve the immune function，and be conducive to the neurological development of the children，which is worthy of clinical promotion. |
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