| 引用本文:田珂1，庞宏永1，朱岩2.四妙勇安汤加减治疗下肢动脉硬化闭塞症患者的疗效和其部分机制[J].世界中医药,2019,(02):. |
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| 四妙勇安汤加减治疗下肢动脉硬化闭塞症患者的疗效和其部分机制 |
| Clinical Observation and Exploration of Part Mechanism of Simiao Yongan Decoction in Treating Arteriosclerosis Obliterans |
| 投稿时间：2018-03-31 |
| DOI：10.3969/j.issn.1673-7202.2019.02.042 |
| 中文关键词: 四妙勇安汤 下肢动脉硬化闭塞症 血液流变学 纤维素原 肿瘤坏死因子-α 白细胞介素-18 疗效机制 |
| English Keywords:Simiao Yongan Decoction Arteriosclerosis Obliterans Hemorheology Fib Influence factors TNF-α,IL-18 Therapeutic mechanism |
| 基金项目:河南省教育厅科学技术研究重点项目(13A380595) |
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| 中文摘要: |
| 目的：探讨四妙勇安汤加减治疗下肢动脉硬化闭塞症患者的疗效和其部分机。方法：选取2015年1月至2017年12月商丘市第一人民医院收治的下肢动脉硬化闭塞症患者120例，按照随机数字表法随机分为对照组和观察组，每组60例。分别进行西医常规基础治疗和清洁换药，对照组加以盐酸法舒地尔注射液静脉滴注治疗,观察组在对照组基础上加用四妙勇安汤口服。分别在治疗前和治疗4周后，对2组患者的临床症状、炎性指标、血液流变学等情况进行对比评估，并进行统计分析。结果：4周治疗后，2组肿瘤坏死因子-α(TNF-α)、白细胞介素-18(IL-18)、全血黏度、血浆黏度、纤维素原水平均较治疗前明显降低，差异有统计学意义（P<0.05），且观察组的改善优于对照组，差异有统计学意义（P<0.05）；2组踝肱指数(ABI)及趾肱指数(TBI)均明显提高，差异有统计学意义（P<0.05），且观察组的提高优于对照组，差异有统计学意义（P<0.05）；2组患者临床症状在溃疡面积、溃疡深度、肉芽生长、溃疡炎肿、疼痛等方面评分均明显降低，差异有统计学意义（P<0.05），观察组的改善优于对照组，差异有统计学意义（P<0.05）。结论：四妙勇安汤加减治疗下肢动脉硬化闭塞症可取得良好的临床疗效，这可能与改善患者血液流变，清除炎性反应递质有关。 |
| English Summary: |
| To use Simiao Yongan Decoction to treat arteriosclerosis obliterans with heat-toxin amassment syndrome,and to observe the clinical efficacy to compare the changes of related indexes before and after treatment for analysis of its action mechanism.Methods:A total of 120 arteriosclerosis obliterans patients with heat-toxin amassment syndrome treated in First People's Hospital of Shangqiu City from January 2015 to December 2017 were selected and divided into the observation group and the control group,with 60 cases in each group.The two groups were treated with conventional western medicine therapy and clean dressing,and the control group was given fasudil hydrochloride injection intravenous infusion therapy,while the observation group was treated with Simiao Yongan Decoction based on the same treatment of the control group.Before treatment and 4 weeks after treatment,the clinical symptoms,inflammatory markers and hemorheology of the 2 groups were compared and evaluated,and the results were statistically analyzed.Results:After 4 weeks of treatment,the TNF-α,IL-18,whole blood viscosity,plasma viscosity,Fib levels of the 2 groups were significantly decreased compared with before the treatment (P<0.05),and the observation group improved more than those in the control group (P<0.05).The ABI and TBI measured by ultrasound method were significantly increased (P<0.05),which were increased more obviously than those of the control group (P<0.05).The comparison of 2 groups showed that the clinical symptoms such as the ulcer dimension,ulcer depth,granulation,inflammatory swelling,pain and ulcer score were significantly decreased (P<0.05),and the observation group improved more than those in the control group (P<0.05).Conclusion:Simiao Yongan Decoction can have effective clinical effects in the treatment of arteriosclerosis obliterans,which may be related to improving hemorrheology and eliminating inflammatory factors. |
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