| 引用本文:刘懿1，刘雁2，李星国2.白芍总苷胶囊治疗皮炎湿疹的临床疗效及对外周血Th1/Th2的影响[J].世界中医药,2019,(02):. |
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| 白芍总苷胶囊治疗皮炎湿疹的临床疗效及对外周血Th1/Th2的影响 |
| Clinical Efficacy of Total Glucoside of Paeony on Dermatitis and Eczema and its Effects on Th1/Th2 in Peripheral Blood |
| 投稿时间：2018-11-06 |
| DOI：10.3969/j.issn.1673-7202.2019.02.044 |
| 中文关键词: 白芍总苷胶囊 皮炎 湿疹 临床疗效 免疫功能 |
| English Keywords:Total Paeony glucoside capsule Dermatitis Eczema Clinical efficacy Immune function |
| 基金项目:2015年大连市医学科学研究计划项目（1511002） |
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| 中文摘要: |
| 目的：探讨白芍总苷胶囊治疗皮炎湿疹的临床疗效及对外周血Th1/Th2的影响。方法：选取2015年12月至2017年12月南溪山医院收治的皮炎湿疹患者130例为研究对象，按照随机数字表法随机分为对照组和观察组，每组65例。对照组患者采用常规西药治疗，观察组在对照组的基础上联合白芍总苷胶囊进行治疗，2组均连续治疗4周。比较2组临床疗效、治疗前后体液免疫功能及相关炎性反应指标水平，统计2组治疗过程中不良反应发生情况。结果:治疗后观察组与对照组的总有效率分别为95.38%、83.08%，观察组总有效率显著高于对照组,差异有统计学意义（P<0.05）。治疗后2组Th1、Th2比例及嗜酸性粒细胞（EOS）水平均较治疗前显著下降,差异有统计学意义（P<0.05），且观察组显著低于对照组,差异有统计学意义（P<0.05）；治疗后2组Th1/Th2比值较治疗前升高,差异有统计学意义（P<0.05），且观察组显著高于对照组,差异有统计学意义（P<0.05）。治疗后2组血清中IL-2、IL-5、IL-10水平均较治疗前下降,差异有统计学意义（P<0.05），且观察组均低于对照组,差异有统计学意义（P<0.05）。观察组治疗过程不良反应发生率为9.23%，对照组不良反应发生率为12.31%，2组不良反应发生率差异无统计学意义（P>0.05）。结论:白芍总苷胶囊治疗皮炎湿疹可有效缓解患者临床症状，调控外周血中Th1/Th2比值水平，抑制自身免疫反应及炎性反应，临床效果显著。 |
| English Summary: |
| To investigate the effects of total glucoside of paeony on dermatitis and eczema and its effect on ratio of peripheral blood helper T1 cells to T2 cells (Th1/Th2) in peripheral blood. Methods:A total of 130 patients with dermatitis and eczema treated in Nanxishan Hospital of Guangxi Zhuang Autonomous Region from December 2015 to December 2017 were selected as the study objects，and they were divided into observation group and control group by random digital table method，65 cases in each group. Control group was given conventional western medicine therapy，observation group was treated with total glucoside of paeony based on the control group，and 2 groups were treated continuously for 4 weeks. The clinical efficacy，humoral immune function and related inflammatory indexes before and after treatment of 2 groups were compared; the adverse reactions in the course of treatment in 2 groups of patients were statisticsed. Results:After treatment，the total effective rate of observation group and control group were 95.38%，83.08% respectively，the total effective rate of observation group was significantly higher than control group (P<0.05); The percentage of Th1，Th2 cells and EOS in 2 groups were significantly lower than that before treatment (P<0.01)，and observation group was significantly lower than that in control group (P<0.01); The Th1/Th2 ratio in 2 groups after treatment was significantly higher than that before treatment (P<0.011)，and observation group was significantly higher than that in control group (P<0.05). The levels of IL-2，IL-5 and IL-10 in 2 groups after treatment were significantly lower than those before treatment (P<0.01)，and observation group was significantly lower than those in control group (P<0.01). The incidence of adverse reactions during treatment in observation group was 9.23%，and the incidence of adverse reactions during treatment in control group was 12.31%，there was no significant difference in the incidence of adverse reactions between 2 groups (P>0.05). Conclusion:The treatment of dermatitis and eczema with total paeony glucoside capsule can effectively relieve the clinical symptoms，regulate the ratio of Th1/Th2 in peripheral blood，inhibit autoimmune reaction and inflammation，and the clinical effect is remarkable. |
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