世界中医药

目的：观察醒脾养儿颗粒联合西药治疗小儿消化不良性腹泻对免疫功能的影响及临床疗效。方法：选取2017年3月至2018年6月昆明市儿童医院儿科收治的消化不良性腹泻患儿110例，按照随机数字表法随机分为观察组和对照组，每组55例。对照组患儿给予常规治疗（蒙脱石散+复合维生素B片），观察组患儿应用醒脾养儿颗粒联合西药治疗（醒脾养儿颗粒+酪酸梭菌活菌散）。比较2组患儿治疗总有效率、临床症状（大便性状、腹泻、腹胀、发热）改善时间、治疗前后免疫功能指标（CD3+、CD4+、CD8+、CD4+/CD8+）变化及不良反应发生率。结果：观察组患儿治疗总有效率为94.5%（52/55），高于对照组的81.8%（45/55），2组比较差异有统计学意义（P<0.05）；观察组症状改善时间明显短于对照组，P<0.05；治疗前，2组患儿免疫功能各项指标比较，差异无统计学意义，P>0.05；治疗后，2组患儿CD3+、CD4+、CD8+、CD4+/CD8+均有所改善，但观察组明显患儿CD3+、CD4+、CD4+/CD8+水平明显优于对照组，CD8+水平低于对照组，P<0.05；观察组患而治疗期间不良反应发生率为5.5%（3/55），对照组患儿为9.1%（5/55），P>0.05。结论：醒脾养儿颗粒对小儿消化不良性腹泻效果显著，安全性高，值得临床推广应用。

English Summary:

To investigate the therapeutic effects of Xingpi Yanger Granules combined with Western medicine on dyspepsia in children and its effects on immune function.Methods:A total of 110 children with dyspeptic diarrhea admitted to department of pediatric clinic of Kunming Children's Hospital from March 2017 to June 2018 were enrolled in the observation group and the control group according to the random number table method.The control group received routine treatment (montmorillonite powder + multivitamin B tablets)，and the children in the observation group were treated with Xingpi Yanger Granules combined with Western medicine (Xingpi Yanger Granules + Clostridium butyricum).The total effective rate，the time of improvement of clinical symptoms，the changes of immune function indexes before and after treatment (cluster of differentiation 3+ (CD3+) CD4+，CD8+，CD4+/CD8+) and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment of children in the observation group was 94.5% (52/55) higher than that of 81.8% (45/55) in control group (P<0.05).The improvement time of symptoms such as stool traits，diarrhea，bloating and fever in the observation group They were significantly shorter than the control group (P<0.05).Before treatment，the immune function indexes of 2 groups of children were not statistically significant (P>0.05).After treatment，CD3+，CD4+，CD8+，CD4+/CD8+ of children in the 2 groups were improved，but the observation group was significantly better than the control group，while the CD8+ level was lower than the control group (P<0.05).The incidence of adverse reactions in the observation group was 5.5% (3/55)，and that in the control group was 9.1% (5/55) (P>0.05).Conclusion:Xingpi Yanger Granule combined with western medicine is effective in the treatment of dyspepsia in children with diarrhea and can significantly improve the cellular immunological function of children.It is safe and worthy of clinical application.

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