| 引用本文:沈海广，唐远平，姚仲伟，王柱.小儿肺咳颗粒联合易坦静对支气管肺炎患儿疗效及肺功能和炎性反应递质的影响[J].世界中医药,2019,(02):. |
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| 小儿肺咳颗粒联合易坦静对支气管肺炎患儿疗效及肺功能和炎性反应递质的影响 |
| Study on Curative Effects of Xiao'er Feike Granules Combined with Yitanjing (Ambroxol Hydrochloride and Clenbuterol Hydrochloride Oral Solution) on Children with Bronchial Pneumonia and Its Effects on Pulmonary Function and Inflammatory Mediators |
| 投稿时间：2018-01-29 |
| DOI：10.3969/j.issn.1673-7202.2019.02.046 |
| 中文关键词: 小儿肺咳颗粒 易坦静 支气管肺炎 肺功能 炎性反应递质 小儿 咳嗽 |
| English Keywords:Xiao'er Feike Granules Yitanjing Bronchial pneumonia Pulmonary function Inflammatory mediators Children Cough |
| 基金项目:广东省科技计划项目(509087577041) |
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| 中文摘要: |
| 目的：探讨小儿肺咳颗粒联合易坦静对支气管肺炎患儿疗效及肺功能和炎性反应递质的影响。方法：选取2017年1月至2017年12月广东省妇幼保健院收治的支气管肺炎患儿98例，按照随机数字表法分为对照组和观察组，每组49例。对照组采用易坦静治疗，观察组在对照组基础上结合小儿肺咳颗粒治疗。2组疗程均为10 d。比较2组治疗疗效，治疗前后主要症状积分、肺功能及炎性反应递质变化及不良反应发生情况。结果：观察组治疗有效率（93.88%）高于对照组（73.47%），差异有统计学意义（P<0.05）。2组治疗后咳嗽、喘息和咯痰症状积分降低（观察组：t=22.626、25.554、29.063，对照组：t=13.481、15.814、21.600，P<0.05）；观察组治疗后咳嗽、喘息和咯痰症状积分低于对照组（t=18.087、17.850、22.170，P<0.05）。2组治疗后第一秒钟用力呼气容积（FEV1）、用力肺活量（FVC）和呼吸气流量分值（PEF）增加（观察组：t=21.507、20.238、21.206，对照组：t=10.501、10.470、13.359，P<0.05）；观察组治疗后FEV1、FVC和PEF高于对照组（t=11.533、9.134、8.544，P<0.05）。2组治疗后血清白细胞介素-4（IL-4）、C反应蛋白（CRP）和白细胞介素-18（IL-18）水平降低（观察组：t=21.658、22.520、18.904，对照组：t=12.283、10.513、8.987，P<0.05）；观察组治疗后血清IL-4、CRP和IL-18水平低于对照组（t=12.988、13.203、14.793，P<0.05）。观察组不良反应发生率（8.16%）低于对照组（28.57%），差异有统计学意义（P<0.05）。结论：小儿肺咳颗粒联合易坦静对支气管肺炎患儿疗效显著，可明显改善患者肺功能及减轻炎性反应，不良反应小。 |
| English Summary: |
| To study curative effects of Xiao'er Feike Granules combined with Yitanjing (ambroxol hydrochloride and clenbuterol hydrochloride oral solution) on children with bronchial pneumonia and its effects on pulmonary function and inflammatory mediators.Methods:A total of 98 children with bronchial pneumonia admitted to Guangdong Maternity and Child Health Care Hospital from January 2017 to December 2017 were selected and divided into observation group (49 cases) and control group (49 cases) according to random table method.The control group was given Yitanjing，on the basis of which the observation group was given Xiao'er Feike Granules.The two groups were treated for 10 days.The curative effects of the two groups was compared including the main symptom score，the change of the lung function and the inflammatory mediators before and after the treatment，and the occurrence of adverse reactions were compared.Results:The total effective rate in the observation group (93.88%) was higher than that of the control group (73.47%) (P<0.05).Symptom scores including cough，wheezing，and expectoration decreased in two groups after treatment (observation group：t=22.626，25.554，29.063，control group：t=13.481，15.814，21.600，P<0.05); the symptom scores of the observation group after treatment of cough，wheezing and expectoration were lower than those of control group (t=18.087，17.850，22.170，P<0.05).After treatment，FEV1，FVC and PEF increased in two groups (observation group：t=21.507，20.238，21.206，control group：t=10.501，10.470，13.359，P<0.05); after treatment，FEV1，FVC and PEF in observation group were higher than those in control group (t=11.533，9.134，8.544，P<0.05).Serum IL-4，CRP and IL-18 levels decreased in two groups after treatment (observation group：t=21.658，22.520，18.904，control group：t=12.283，10.513，8.987，P<0.05); and the levels of serum IL-4，CRP and IL-18 levels after treatment in the observation group were lower than those in the control group (t=12.988，13.203，14.793，P<0.05).The incidence of adverse reaction in the observation group (8.16%) was lower than that of the control group (28.57%) (P<0.05).Conclusion:Xiao'er Feike Granules combined with Yitanjing has good curative effects in the treatment of children with bronchial pneumonia，and it can significantly improve lung function and reduce inflammation and adverse reaction，which is worthy of researching. |
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