| 引用本文:李凌云1，陈文辉2，吴钱红1，孙妍彦1.二仙地黄汤联合胰岛素治疗2型糖尿病的临床研究及对血脂和ET-1的影响[J].世界中医药,2019,(03):. |
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| 二仙地黄汤联合胰岛素治疗2型糖尿病的临床研究及对血脂和ET-1的影响 |
| Clinical Research of Erxian Dihuang Decoction Combined with Insulin on Type 2 Diabetes Mellitus and Its Effects on Serum Lipid，and Endothelin-1 |
| 投稿时间：2018-12-19 |
| DOI：10.3969/j.issn.1673-7202.2019.03.038 |
| 中文关键词: 2型糖尿病 二仙地黄汤 胰岛素 血脂 内皮素-1 血糖 血流变学 |
| English Keywords:Type 2 diabetes mellitus Erxian Dihuang Decoction Insulin Blood lipid Endothelin-1 Blood glucose Hemorheology |
| 基金项目:广西自然科学基金项目（2015GXNSFAA139119） |
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| 中文摘要: |
| 目的：探讨二仙地黄汤联合胰岛素治疗2型糖尿病（T2DM）的临床效果及对患者血脂、内皮素-1（ET-1）、血糖和血流变学指标水平的影响。方法：选取2015年6月至2016年2月广西壮族自治区南溪山医院收治的T2DM患者96例作为研究对象，按照随机数字表法随机分为对照组和观察组,每组48例。对照组采用胰岛素降糖治疗，观察组在对照组的基础上加用二仙地黄汤。2组均连续治疗4周。统计并计算2组临床疗效；比较2组患者血脂、ET-1水平、血糖和血流变学指标的变化。结果：观察组总有效率为95.83%，显著高于对照组的83.33%（P<0.05）；治疗后2组TC、TG、LDL-C、ET-1及FPG、2 hPG、HbAlc等指标水平，均较治疗前显著下降，HDL-C较治疗前显著升高（P<0.05或P<0.01），组间比较差异有统计学意义（P<0.05或P<0.01）；治疗后2组全血黏度、血浆黏度、红细胞比容、红细胞刚性指数均较治疗前显著下降，红细胞变形指数较治疗前显著升高（P<0.05或P<0.01），组间比较差异有统计学意义（P<0.05或P<0.01）。结论:二仙地黄汤联合胰岛素治疗T2DM患者的临床效果确切，可有效降控制患者血糖、血脂水平，并能缓解机体血液高凝状态，降低ET-1水平，进而更利于病情的恢复。 |
| English Summary: |
| To investigate the clinical effects of Erxian Dihuang Decoction combined with insulin in the treatment of type 2 diabetes mellitus(T2DM)and its effects on blood lipid，endothelin-1(ET-1)，blood glucose and hemorheology. Methods:A total of 96 patients with T2DM were selected from June 2015 to February 2016 and randomly divided into the control group(n=48)and the observation group(n=48)according to random number table method. The control group was treated with insulin hypoglycemic therapy，while the observation group was treated with Erxian Dihuang Decoction on the basis of the control group. Both groups received continuous treatment for 4 weeks. The clinical efficacy of the 2 groups was calculated. The changes of blood lipid，ET-1 level，blood glucose and hemorheology indexes in the 2 groups were detected and compared. Results:The total effective rate of the observation group was 95.83%，which was significantly higher than that of the control group(83.33%)(P<0.05). After treatment，the blood lipid levels of TC，TG，LDL-C and other indicators in the 2 groups，as well as the blood glucose levels of ET-1，FPG，2 hPG and HbAlc，were significantly decreased and HDL-C was significantly increased(P<0.05 or P<0.01). The differences between the 2 groups were significant(P<0.05 or P<0.01). After treatment，the whole blood viscosity，plasma viscosity，erythrocyte specific volume and erythrocyte rigidity indexes of the 2 groups were significantly decreased while the erythrocyte deformation index was significantly increased(P<0.05 or P<0.01). The differences between the 2 groups were significant(P<0.05 or P<0.01). Conclusion:Erxian Dihuang Decoction combined with insulin has definite clinical effects on T2DM patients. It can effectively reduce the blood glucose and lipid levels of patients as well as relieve the hypercoagulation state of blood and reduce the levels of ET-1，contributing to the recovery of the disease. |
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