| 引用本文:程益清1，夏晶1，曹帅1，李丽敏1，付泽晓1，周如洁1，刘冠萍2，梁云飞2，毛秀红1，朱小凤2，季申1.注射用血栓通中三七元素迁移的规律[J].世界中医药,2019,(04):. |
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| 注射用血栓通中三七元素迁移的规律 |
| Migration of Elements in Panax Notoginseng from Thrombus Scavenger Injection |
| 投稿时间：2019-03-10 |
| DOI：10.3969/j.issn.1673-7202.2019.04.004 |
| 中文关键词: ICP-MS法 三七 注射用血栓通 三七总皂苷 重金属及有害元素 微波消解法 元素迁移 无机元素 |
| English Keywords:Inductively coupled plasma mass spectrometry Panax notoginseng Thrombus scavenger injection Panax noteginseng saponins Heavy metal and hazard elements Microwave digestion Migration of elements Inorganic elements |
| 基金项目:国家中药标准化项目（ZYBZH-C-GX-09）；科技部重点研发专项（2017YFC1700800）；上海科委技术标准专项（18DZ2200900）；广西壮族自治区科学技术厅重大专项计划（2015AC05038） |
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| 中文摘要: |
| 目的：分析注射用血栓通中三七从原料到成品全过程的元素迁移规律，以便更好地控制成品中元素杂质。方法：采用ICP-MS法全面分析三七药材、三七总皂苷（中间体）和注射用血栓通中21种元素的含量。结果：21种元素的标准曲线相关系数r均在0.999以上，回收率在92.71%～107.07%之间，RSD均在5%以内。三七药材中铝、铁含量较高，铅、砷、汞、镉、铜符合中华人民共和国药典的相关规定，三七总皂苷（中间体）和注射用血栓通中多数元素均未检出或含量极低。结论：注射用血栓通的提取工艺可有效去除三七中大部分元素，重金属及有害元素也降到较低水平。 |
| English Summary: |
| To analyze the migration of elements in Thrombus Scavenger Injection from material to product，and to control the elemental impurities in products.Methods:The quantities of 21 elements in Panax notoginseng，Panax noteginseng saponins and Thrombus Scavenger Injection were determined by ICP-MS.Results:The correlative coefficients of standard curves of 21 elements surpassed 0.999，with the average recoveries ranged from 92.71% to 107.07% and their RSDs within 5%.The quantities of Al and Fe in Panax notoginseng were higher，while Pb，As，Hg，Cd，Cu was less than the standards of Chinese Pharmacopoeia.Most elements in Panax noteginseng saponins and Thrombus Scavenger Injection were not detected or were extremely low.Conclusion:The quantities of the heavy metal and hazard elements and other elements in Panax notoginseng were greatly reduced by the extraction process of Thrombus Scavenger Injection. |
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