| 引用本文:张历元1，李元文2，张丰川2，姜晓媛1，胡博2，肖飞3.复方紫草油联合加味过敏煎治疗对特应性皮炎模型小鼠的干预作用与机制研究[J].世界中医药,2019,(06):. |
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| 复方紫草油联合加味过敏煎治疗对特应性皮炎模型小鼠的干预作用与机制研究 |
| Study on the Intervention Effect and Mechanism of Compound Compound Radix Arnebiae Oil Combined with Jiawei Allergic Decoction on Mice with Atopic Dermatitis |
| 投稿时间：2019-03-29 |
| DOI：10.3969/j.issn.1673-7202.2019.06.011 |
| 中文关键词: 特应性皮炎 白细胞介素 复方紫草油 小鼠 实验 机制 |
| English Keywords:Atopic dermatitis Interleukin Compound Radix Arnebiae Oil Mice ExperimentMechanism |
| 基金项目:北京中医药大学横向科研项目（HX201706）——复方紫草油治疗慢性湿疹（血虚风燥证）的临床及动物实验研究 |
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| 中文摘要: |
| 目的：研究复方紫草油、复方紫草油联合加味过敏煎对特应性皮炎小鼠的治疗作用，探讨中药内外结合在特应性皮炎治疗中的意义。方法：DNCB法诱导造模成功后设立随机平行对照组，采用仅外用紫草油、紫草油+加味过敏煎、仅外用吡美莫司、氧化锌+氯雷他定等不同方案对小鼠特应性皮炎模型进行干预，记录并评价其皮损恢复情况，并用ELISA法检测其血清IL-4、IL-7、IL-17水平。结果：各观察组均能有效改善特应性皮炎小鼠皮损，吡美莫司、复方紫草油+加味过敏煎的整体疗效均显著优于氯雷他定+氧化锌组。复方紫草油+加味过敏煎组的痊愈率逊于吡美莫司组，但二者整体皮损疗效无统计学意义。各观察组间IL-4、IL-17水平差异无统计学意义(P>005)，IL-7水平差异有统计学意义(P<005)：加味过敏煎联合紫草油组IL-7水平最高，且显著高于紫草油组（P<001）和氯雷他定联合氧化锌组，差异有统计学意义（P<005）。结论：复方紫草油可有效改善模型小鼠皮损，降低小鼠血清IL-4，一定程度升高IL-7并抑制IL-17水平，可以用于特应性皮炎的治疗；联合口服加味过敏煎对皮损肥厚苔藓化的改善更为显著，可能与其能更确切地升高IL-7水平有关，口服中药汤剂具有一定临床意义。 |
| English Summary: |
| To study the therapeutic effect of Compound Radix Arnebiae Oil and Compound Radix Arnebiae Oil combined with flavored allergy decoction on atopic dermatitis mice, and to explore the significance of combination of internal and external Chinese medicine in the treatment of atopic dermatitis.Methods:Randomized parallel control group was set up after DNCB method induce to establish model successfully . Different schemes were used to intervene the model of atopic dermatitis in mice, such as only external use of Radix Arnebiae Oil, Radix Arnebiae Oil+flavored allergy decoction,only external use of Puccoon Oil+Flavored allergy decoction, Pimecrolimus, Zinc oxide+Loratadine etc. The recovery of skin lesions was recorded and evaluated. The Serum of IL-4, IL-7 and the level of IL-17 were detected by ELISA. Results: Every groups can improve the symptoms of Skin lesions in mice with atopic dermatitis effectively, whole curative effect of Pimecrolimus、Compound Radix Arnebiae Oil+flavored allergy decoction was superior to Loratadine+Zinc oxide group. The cure rate of Compound Radix Arnebiae Oil+flavored allergy decoction was lower than pimecrolimus group. However, the two groups were not significantly different from each other. The level of IL-4 and IL-7 was not statistically signficant (P>0.05).The Level of IL-7 the difference was statistically significant(P<0.05); The level of IL-7 in flavored allergy decoction combined with Radix Arnebiae Oil group was the highest, which was significantly higher than that of Radix Arnebiae Oil group and Loratadine combined with Zinc oxide group. The difference was statistically significant(P<0.05). Conclusion:Compound Radix Arnebiae Oil can effectively improve the skin lesions of model mice, which reduces mice serum IL-4,and in a certain extent IL-7 was increased and the level of IL-17 was inhibited, which can be used in the treatment of atopic dermatitis.. Radix Arnebiae Oil combined with flavored allergy decoction by oral administration can improve the lichenization of skin lesions more significantly, which may be related to the more exact increase of IL-7 level. Traditional chinese medicine decoction by oral administration has a certain significance in clinic. |
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