世界中医药

目的：基于数据挖掘技术探讨中药复方治疗过敏性紫癜肾炎的用药规律。方法：以中国方剂数据库为检索库，检索治疗“葡萄疫”“紫癜”“血尿”“尿浊”“水肿”的中药方剂，建立中药复方治疗过敏性紫癜肾炎的方剂数据库，并采用Excel、SPSS 200软件进行频数及频率分析、因子分析等，进而对中药复方用药规律进行定量、定性分析并探讨其可能相关机制。结果：中药复方治疗过敏性紫癜肾炎涉及复方449首中药294种高频中药81味，茯苓、甘草、当归、生地黄、黄芩和防风较为常用；在功效方面补气药、理气药、利水消肿药、发散风寒药、补血药选用次数较多。四气以寒、温、平为主；五味以甘、苦、辛为主；以脾经、肺经、心经、肾经、肝经、胃经等6条经脉选用次数较多。最终提取了29个公因子，累积贡献率达100％，其中以补中益气、滋阴补血、利水渗湿为主；通过聚类分析，提取了6个常用得药对或药组。结论：过敏性紫癜肾炎的临床诊疗中，首先应辨明急性活动期和慢性缓解期，急性期以祛风散邪、活血化瘀之法治疗，用发散风寒、利水渗湿、凉血止血功效的中药；慢性期以补益之法，主要用补中益气、滋阴补血功效的中药，并选取相应中药组方治疗。

English Summary:

Based on data mining technology,to explore the medication rules of Chinese herbal compound of Henoch-Schonlein-purpura nephritis (HSPN).Methods:Taking the Chinese prescription database as the retrieval database,the traditional Chinese medicine (TCM) prescription for treating “葡萄疫”,“紫癜”,“血尿”,“尿浊”,“水肿”tingearched to established prescription database of Chinese herbal compound in the treatment of HSPN,and Excel,SPSS 200 software were used for frequency analysis,factor analysis,and then the quantitative and qualitative analysis of the regularity of Chinese herbal compound was conducted and its possible mechanism was discussed.Results:Chinese herbal compound treatment of HSPN involves 449 prescriptions,294 kinds of Chinese medicine,81 flavors of high frequency herbs,Poria,Radix Glycyrrhizae,Radix Angelicae Sinensis,Radix Rehmanniae Recens,Radix Scutellariae and Radix Saposhnikoviae were commonly used; qi-tonifying herbs,qi-flowing regulating herbs,diuresis and edema-removing herbs,dispelling wind-cold herbs and blood-supplementing herbs were most commonly used; cold,warm and neutral of the four properties were commonly used; sweet,bitter and pungent of the five flavors were commonly used; the meridian of spleen,lung,heart,kidney,liver and stomach were most commonly chosen; totally 29 common factors were extracted from the factor analysis and the cumulative contribution rate was 100%,mostly of them were about invigorating spleen-stomach and replenishing qi,nourishing yin and tonifying blood,promoting urination and diffusing dampness; and 6 drug groups were obtained by cluster analysis.Conclusion:In the clinical diagnosis and treatment of HSPN,acute active phase and chronic remission period should be identified first.In the acute phase,the treatment principle should be dispelling wind and pathogenic factors,activating blood and resolve stasis,and using the traditional Chinese medicine for dispelling wind and dissipating cold,eliminating dampness and diuresis,cooling blood for hemostasis.In the chronic remission period,the treatment principle should be invigoration method,traditional Chinese medicine for invigorating spleen-stomach and replenishing qi,nourishing yin and tonifying blood were used,and the corresponding TCM prescriptions were selected to treat the disease.

查看全文查看/发表评论下载PDF阅读器