| 引用本文:何小汝1，王雅琪1，徐柳云2，刘曦2，王勇2，梁新丽1.猴子瘿袋化学成分研究[J].世界中医药,2019,(07):. |
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| 猴子瘿袋化学成分研究 |
| Study on Chemical Constituents from Artocarpus Pithecogallus |
| 投稿时间：2019-06-05 |
| DOI：10.3969/j.issn.1673-7202.2019.07.003 |
| 中文关键词: 波罗蜜 猴子瘿袋 化学成分 分离 三萜 结构鉴定 熊果酸 白桦脂醇 |
| English Keywords:Artocarpus A.pithecogallus Chemical constituents Isolation Triterpenoid Structure identification Ursolic acid Betulin |
| 基金项目:国家自然科学基金项目（21362023）；江西省自然科学基金项目（20151BAB205083）;江西省教育厅课题（GJJ150843） |
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| 中文摘要: |
| 目的：研究波罗蜜属植物猴子瘿袋Artocarpus.Pithecogallus小枝的化学成分。方法：运用硅胶柱色谱、MCI gel树脂、LH-20葡聚糖凝胶(Sephadex LH-20)柱色谱、HPLC、ODS等色谱分离手段，对猴子瘿袋枝叶的95%乙醇提取物的乙酸乙酯部位进行分离纯化，通过其1H-NMR和13C-NMR数据与文献进行对照鉴定其结构。结果：共分离了六个三萜类化合物，分别鉴定为3,25-二羟基羊毛脂烷-8,23(E)-二烯-7,11-二酮(1)，(24R)-环阿屯烷-25-烯-3β,24-二醇(2)，(24R)-环阿屯烷-24,25-二醇-3-酮(3)，熊果酸(4)，桦木酸(5)，白桦脂醇(6)。结论：化合物1、5和6为首次从菠萝蜜属植物中分离获得。 |
| English Summary: |
| To study the chemical constituents of the twigs of Artocarpus.Pithecogallus.Methods：Compounds were isolated and purified by the normal phase silica gel,MCI gel,Sephadex LH-20,HPLC and ODS chromatography.Their structures were identified by comparing the 1H-NMR and 13C-NMR data with those reported in literature.Results：Six triterpenoids were isolated from the ethyl-acetate fraction in 95% ethanol extract of A.Pithecogallus.All isolates were identified as 3,25-dihydroxy lanolin-8,23(E)-diene-7,11-dione(1),(24R)-cycloalkane-25-ene-3,24-diol(2),(24R)-cycloalkane-24,25-diol-3-one(3),ursolic acid(4),birch acid(5）and betulin(6).Conclusion：Compounds 1,5 and 6 were isolated from the genus Artocarpus for the first time. |
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