世界中医药
文章摘要
引用本文:王中方,周佩莉,俞忠,曹阳.醒脑静联合鼠神经生长因子治疗脑出血急诊期的疗效[J].世界中医药,2019,(07):.  
醒脑静联合鼠神经生长因子治疗脑出血急诊期的疗效
Curative Observation on Xingnaojing Combined with Mouse Nerve Growth Factor in Treatment of Cerebral Hemorrhage Emergency Management
投稿时间:2018-12-20  
DOI:10.3969/j.issn.1673-7202.2019.07.020
中文关键词:  脑出血  醒脑静  鼠神经生长因子  神经元特异性烯醇化酶  同型半胱氨酸
English Keywords:Cerebral hemorrhage  Xingnaojing  Mouse nerve growth factor  NSE  Hcy
基金项目:国家中医药重点专科建设项目(ZY044651)
作者单位
王中方,周佩莉,俞忠,曹阳 皖南医学院第二附属医院芜湖241000 
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中文摘要:
      目的:探讨醒脑静联合鼠生长因子(NGF)对脑出血急诊期的临床疗效。方法:选取2016年1月至2018年6月皖南医学院第二附属医院收治的脑出血患者100例作为研究对象,随机分成常规观察组、NGF组、醒脑静组和联合组,每组25例。常规观察组给予胞磷胆碱钠注射液治疗;NGF组在常规观察组基础上肌内注射NGF,1次/d;醒脑静组在常规观察组基础上静脉滴注醒脑静注射液,1次/d;联合组用法用量同上述3组;所有患者均治疗2周。依据NIHSS评分评定患者治疗后临床疗效,比较治疗前后血清神经元特异性烯醇化酶(NSE)、同型半胱氨酸(Hcy)变化,记录脑出血患者脑水肿体积变化。结果:治疗后NGF组、醒脑静组、联合组的NIHSS评分低于常规观察组,其中联合组评分最低,与常规观察组比较,差异有统计学意义(P<0.05);NGF组、醒脑静组、联合组显效率均高于常规观察组(56%),其中联合组显效率最高达到88%,较常规观察组差异有统计学意义(P<0.05);4组患者治疗后血清NSE、Hcy水平值较治疗前明显下降,其中联合组下降值最低[NSE值为(18.51±3.28)μg/mL、Hcy值为(9.55±2.44)μmol/L],NGF组和醒脑静组的NSE、Hcy水平值相近。治疗后NGF组、醒脑静组、联合组脑水肿体积显著低于常规观察组,4组治疗前比较,差异无统计学意义(P>0.05),治疗后4组比较,差异有统计学意义(P<0.05),同组治疗前后比较,差异有统计学意义(P<0.05),NGF组、醒脑静组、联合组治疗后与常规观察组比较,差异有统计学意义(P<0.05)。结论:鼠神经生长因子联合醒脑静用于脑出血急诊期治疗,临床疗效显著。
English Summary:
      To investigate the clinical effect of Xingnaojing combined with mouse nerve growth factor(NGF)in the emergency stage of cerebral hemorrhage.Methods:A total of 100 patients with cerebral hemorrhage were randomly divided into four groups,with 25 patients in each group,which were conventional treatment group,NGF group,Xingnaojing group and combined group; The conventional treatment group was given the treatment of citicoline sodium injection; NGF group on the basis of the conventional treatment group was injected NGF by muscle,once a day.Xingnaojing group were given Xingnaojing on the basis of the conventional treatment group by intravenous drip,once a day.The usage and dosage of combined group was consistent with the above three groups; All patients were treated for 2 weeks.After treatment,the clinical efficacy of patients was evaluated according to NIHSS score.Changes in serum neuron-specific enolase(NSE)and homocysteine(Hcy)before and after treatment were compared,and changes in cerebral edema volume of patients with cerebral hemorrhage were recorded.Results:NGF group,Xingnaojing group and combined group of NIHSS score were lower than the conventional treatment group after treatment,which the lowest score.Combined group compared with the conventional treatment group had statistically significant difference(P<0.05); the markedly efficiency of NGF group,Xingnaojing group and combined group were higher than conventional treatment group(56%),among which the combined group efficiency was up to 88%,which was statistically significant compared with the conventional treatment group(P<0.05); After treatment,serum NSE and Hcy concentrations of patients in the four groups decreased significantly compared with those before treatment,with the lowest decrease in the combined group(NSE=18.51±3.28 g/mL,Hcy=9.55±2.44 mol/L).NGF group and xingnaojing group had similar NSE and Hcy concentration.After treatment,the volume of cerebral edema in NGF group,xingnaojing group and combined group was significantly lower than that in conventional treatment group.There was no statistical significance before treatment in each group(P>0.05),and there was statistical significance after treatment in each group(P<0.05).There was statistical significance before and after treatment in the same group(P<0.05),and there was statistical significance between NGF group,xingnaojing group and combined group and conventional treatment group(P<0.05).Conclusion:Mouse nerve growth factor in combination with Xingnaojing for emergency period in cerebral hemorrhage,the clinical curative effect is distinct,being worthy of promotion.
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