| 引用本文:楚淑芳，赵恒侠，刘德亮，刘雪梅，渠昕，李惠林.白虎加人参汤联合西医治疗对热盛伤津证糖尿病酮症患者的疗效观察：回顾性真实世界研究[J].世界中医药,2019,(07):. |
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| 白虎加人参汤联合西医治疗对热盛伤津证糖尿病酮症患者的疗效观察：回顾性真实世界研究 |
| Effects of Baihu and Renshen Decoction Combined with Western Medicine on the Diabetic Ketosis Patients with Syndrome of Consumption of Fluid due to Intense Heat：A Retrospective Observation Study in Real World |
| 投稿时间：2019-02-01 |
| DOI：10.3969/j.issn.1673-7202.2019.07.025 |
| 中文关键词: 白虎加人参汤 经方 糖尿病酮症 热盛津伤证 |
| English Keywords:Baihu and Renshen Decoction Classical prescription Diabetic ketosis Syndrome of consumption of fluid due to intense heat |
| 基金项目:深圳市科技计划项目（JCYJ20170817094838619）；深圳市医疗卫生三名工程项目（SZSM201512043）；李惠林广东省名老中医药专家传承工作室项目 |
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| 中文摘要: |
| 目的：观察白虎加人参汤联合西医治疗对热盛伤津证糖尿病酮症患者的疗效。方法：选取2014年10月至2017年10月深圳市中医院收治的热盛伤津证糖尿病酮症患者60例进行回顾性分析，根据是否使用白虎加人参汤分为观察组和对照组，每组30例。对照组给予常规西医治疗，观察组在常规西医治疗的基础上加服白虎加人参汤。观察2组患者的临床疗效、血糖达标时间、酮体转阴时间、血β-羟丁酸(β-HBA)、尿酮体，糖代谢指标如空腹血糖（FPG）、餐后2 h血糖（2 hPG）、空腹C肽（FCP）、糖化血红蛋白（HbA1c），胰岛素用量和并发症发生率。结果：与对照组比较，观察组临床疗效明显提高（P<0.05），血糖达标时间、β-HBA转阴时间和尿酮体转阴时间明显缩短（P<0.01），胰岛素用量、并发症发生率亦明显减少（P<0.05）。2组治疗后，与本组治疗前比较，FPG、2 hPG、FCP、血β-羟丁酸和尿酮体均明显下降（P<0.01）；与对照组比较，观察组各血糖指标、血β-羟丁酸和尿酮体下降程度更为明显（P<0.05）。结论：联合白虎加人参汤治疗热盛伤津证糖尿病酮症患者能够提高临床疗效、缩短血糖达标和酮体转阴时间，明显改善患者的糖代谢指标，减少胰岛素用量以及并发症的发生率，值得临床推广应用。 |
| English Summary: |
| To observe the effects of Baihu and Renshen Decoction(BRD）combined with western medicine on the diabetic ketosis patients with syndrome of consumption of fluid due to intense heat.Methods：A total of 60 diabetic ketosis patients with syndrome of consumption of fluid due to intense heat admitted in Shenzhen Traditional Chinese Medicine Hospital from October 2014 to October 2017 were retrospectively selected,and divided into an observation group and a control group,with 30 patients in each group based on whether the use of BRD or not.The control group was given routine western medicine,while the observation group added BRD on the basis of western medicine.The clinical therapeutic effects,glucose-target-time,turning-to-negative time of ketone bodies,serum β-hydroxybutyric acid(β-HBA),urine ketone bodies,the glucose metabolism indexes of Fasting Plasma Glucose(FPG),2-hour postprandial blood glucose(2 hPG),fasting C-peptide(FCP),glycosylated hemoglobin(HbA1c),insulin dosage and the incidence of complications in the 2 groups were observed.Results：Compared with the control group,the clinical therapeutic effect of the observation group was significantly increased(P<0.05),and the glucose-target-time and the turning-to-negative time of serum β-hydroxybutyric and urine ketone bodies were dramatically shortened(P<0.01).The insulin dosage and the incidence of complications were also reduced notably(P<0.05).The blood glucose index including FPG,2 hPG,FCP,serum β-hydroxybutyric and urine ketone bodies in the 2 groups were significantly decreased compared with that before treatment in the same group(P<0.01).Compared with the control group,the blood glucose indexes,serum β-hydroxybutyric and urine ketone bodies in the observation group decreased significantly(P<0.05).Conclusion：Combining with BRD applying to diabetic ketosis patients with syndrome of consumption of fluid due to intense heat could improve the clinical therapeutic effects,shorten the glucose-target-time and the turning-to-negative time of serum β-HBA and urine ketone bodies,ameliorate the blood glucose indexes,reduce the insulin dosage and the incidence of complications in patients,and therefore it is worthy of clinical application. |
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