| 引用本文:姜顺顺，郑英兰，范丽青.健脾理气中药治疗肝郁脾虚型消化不良患者的临床效果及对血浆、胆囊收缩素、胃促生长素的影响[J].世界中医药,2019,(07):. |
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| 健脾理气中药治疗肝郁脾虚型消化不良患者的临床效果及对血浆、胆囊收缩素、胃促生长素的影响 |
| Clinical Observation on Invigorating Spleen and Regulating Qi Chinese Medicine in the Treatment of Dyspepsia Patients with Liver Depression and Spleen Deficiency Syndrome and Study on the Effects on Plasma，Cholecystokinin and Ghrelin |
| 投稿时间：2018-07-20 |
| DOI：10.3969/j.issn.1673-7202.2019.07.035 |
| 中文关键词: 肝郁脾虚 消化不良 疏肝理气汤 胃动素 胆囊收缩素 胃促生长素 中西医结合疗法 临床疗效 |
| English Keywords:Liver depression and spleen deficiency Dyspepsia Shugan Liqi Decoction Motilin Cholecystokinin Gastrosomatotropin Integrated Chinese and western medicine therapy Clinical efficacy |
| 基金项目:山东科学技术厅科研项目(EK110371) |
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| 目的：观察健脾理气中药对肝郁脾虚型消化不良疾病的治疗效果，同时研究对机体血浆胃泌素、胃动素、胆囊收缩素、胃促生长素指标的影响。方法：选取2016年7月至2017年10月青岛大学附属中心医院收治的经中医辨证分型为肝郁脾虚型消化不良患者104例作为研究对象，按照患者治疗的自愿原则将患者分为对照组和观察组，每组52例。对照组患者采用西药治疗（口服多潘立酮片+雷尼替丁胶囊），观察组患者采用中药方剂治疗（疏肝健脾汤剂），14 d为1个疗程，连续服用6个疗程。观察2组患者临床治疗效果，统计分析治疗前后患者血浆胃泌素、胃动素，胆囊收缩素、胃促生长素水平的变化。结果：治疗后对照组临床治疗有效率为75.00%（39/52），观察组临床治疗有效率为92.31%（48/52），差异有统计学意义（P<0.05）；治疗前2组血浆胃泌素、胃动素比较，差异无统计学意义（P>0.05），治疗后对照组泌素、胃动素分别为（41.8±5.7）pg/mL、（227.8±7.4）pg/mL，观察组治疗后泌素为（44.7±5.4）pg/mL、胃动素为（241.7±8.5）pg/mL，组间比较，差异有统计学意义（P<0.05）；治疗前2组胆囊收缩素（CCK）、胃促生长素（Ghrelin）变化比较，差异无统计学意义（P>0.05），治疗后对照组与观察组CCK值分别为（65.32±4.24）pg/mL、（71.06±5.23）pg/mL，Ghrelin分别为（231.04±23.64）pg/mL、（253.45±24.52）pg/mL，差异有统计学意义（P<0.05）。结论：健脾理气中药合成汤剂后可以有效改善肝郁脾虚型消化不良患者的症状，促进胃动素、胃泌素的分泌，改善胃促生长素的水平，增加了患者的食欲，增加胆囊的收缩功能，增强免疫功能，提高患者的生命质量。 |
| English Summary: |
| To observe the therapeutic effect of invigorating spleen and regulating qi Chinese Medicine on dyspepsia of liver depression and spleen deficiency syndrome，and study the change of the indexes of plasma gastrin，motilin，cholecystokinin and ghrelin in the body.Methods：A total of 104 patients with dyspepsia of liver depression and spleen deficiency syndrome treated by traditional Chinese medicine from July 2016 to October 2017 in Central Hospital Affiliated to Qingdao University were chosen.They were divided into a control group and an observation group according to the principle of voluntary treatment，and 52 cases in each group.The patients in the control group were treated with western medicine(oral domperidone tablets+ranitidine capsules).The patients in the observation group were treated with traditional Chinese medicine(Shugan Jianpi Decoction).14 days were as one course of treatment，and last for 6 consecutive courses.The clinical effects of the 2 groups of patients were observed.The changes of the levels of plasma gastrin，motilin，cholecystokinin and ghrelin in patients before and after treatment were statistically analyzed.Results：1）The total effective rate of the control group after treatment was 75.00%(39/52)，and the total effective rate of the observation group was 92.31%(48/52).The differences were with statistical significance in the 2 sets of data results(P<0.05).2）There were no differences in plasma gastrin(GAS)and motilin(MTL)between the 2 groups before treatment(P>0.05).After treatment，the GAS and MTL values in the control group were(41.8±5.7)pg/mL，(227.8±7.4)pg/mL.The GAS in the observation group was(44.7±5.4)pg/mL and the MTL was(241.7±8.5)pg/mL after treatment.There were statistical differences compared between the 2 groups(P<0.05).3）There were no statistical significance of CCK and Ghrelin in the 2 groups before treatment(P>0.05).The CCK values in the control and observation groups after treatment were(65.32±4.24)(71.06±5.23)pg/mL and Ghrelin were(231.04±23.64)pg/mL and(253.45±24.52)pg/mL respectively，all of which were with statistical significance(all P<0.05).Conclusion：Invigorating spleen and regulating qi Chinese Medicine can effectively improve the symptoms of patients with dyspepsia due to liver depression and spleen deficiency，promote the secretion of motilin and gastrin，improve the level of gastric somatotropin，increase the appetite of patients and increase the gallbladder's function of contraction，enhance immune function and improve the quality of life of patients. |
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