世界中医药
文章摘要
柴胡加龙骨牡蛎汤治疗永久性心房纤颤合并失眠的临床效果评价
Clinical Effects Evaluation of Chaihu Plus Longgu Muli Decoction on Permanent Atrial Fibrillation Complicated with Insomnia
投稿时间:2019-02-20  
DOI:10.3969/j.issn.1673-7202.2019.07.039
中文关键词: 柴胡加龙骨牡蛎汤  经典方剂  永久性心房纤颤  失眠  睡眠指数  中医证候  随机对照  疗效评价
英文关键词: Chaihu Plus Longgu Muli Decoction  Classic formula  Permanent atrial fibrillation  Insomnia  Sleep index  TCM syndrome  Randomized control  Effect evaluation
基金项目:北京市自然科学基金资助项目(7172188)
作者单位
谢冰昕1,李勤1,褚瑜光2,胡元会2,李树斌1,吴宝1 1 中国中医科学院广安门医院南区,北京,102600
2 中国中医科学院广安门医院,北京,100053 
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中文摘要:
      目的:评价柴胡加龙骨牡蛎汤治疗永久性心房纤颤合并失眠患者的疗效。方法:选取2017年6月至2018年6月中国中医科学院广安门医院南区收治的永久性心房纤颤合并失眠患者60例作为研究对象,按照简单随机的方法分为观察组和对照组,每组30例。在房颤基本治疗的基础上,观察组给予柴胡加龙骨牡蛎汤颗粒剂,对照组给予谷维素片,治疗周期为4周。采用匹兹堡睡眠指数量表(PSQI)评价治疗失眠的效果以及对中医证候的改善情况。结果:1)2组治疗前后PSQI评分均有所下降,其中观察组较对照组下降更加明显,差异有统计学意义(P<0.05);2)观察组在治疗乏力、头晕、头痛、烦躁、心悸、胸闷气短、多汗、纳差、口干口苦症状方面均有所改善,其中在治疗头晕、头痛方面较对照组更有效(P<0.05),在治疗健忘方面无明显疗效。对照组在治疗头晕、头痛、烦躁症状方面有所改善,在治疗乏力、心悸、胸闷气短、健忘、多汗、口干口苦方面无明显疗效。结论:柴胡加龙骨牡蛎汤治疗永久性心房纤颤合并失眠具有良好效果。
英文摘要:
      To evaluate the efficacy of Chaihu Plus Longgu Muli Decoction in the treatment of patients with permanent atrial fibrillation complicated with insomnia.Methods:A total of 60 patients with permanent atrial fibrillation complicated with insomnia admitted to the Southern Branch of Guang'anmen Hospital,China Academy of Chinese Medical Sciences from June 2017 to June 2018 were selected as research objects,and they were randomly divided into a treatment group and a control group,with 30 cases in each group.On the basis of basic treatment of atrial fibrillation,the treatment group was treated with Chaihu Plus Longgu Muli Decoction Granules,while the control group was treated with oryzanol.The treatment cycle was 4 weeks.The Pittsburgh Sleep Quality Index(PSQI)was used to evaluate the effects of treatment for insomnia and the improvement of TCM syndromes.Results:1)The PSQI scores of the 2 groups were decreased before and after treatment,and the decrease in the treatment group was more obvious than that in the control group,where the difference was statistically significant(P<0.05).2)The TCM symptoms of fatigue,dizziness,headache,irritability,palpitations,chest tightness,shortness of breath,excessive sweating,anorexia,dry mouth and bitter taste in the mouth were improved in the treatment group.It was more effective in treating dizziness and headache in the treatment group than that in the control group(P<0.05)and there was no obvious effect in treating forgetfulness.The TCM symptoms of dizziness,headache and irritability were improved in the control group and there was no obvious effect in treating fatigue,palpitations,chest tightness,shortness of breath,forgetfulness,sweating,dry mouth and bitter taste in the mouth.Conclusion:Chaihu Plus Longgu Muli Decoction has a good effect in the treatment of permanent atrial fibrillation complicated with insomnia.
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