| 引用本文:管惠静，杜丹，孙明祎，汲泓.四君子汤加减治疗慢性心力衰竭气虚痰瘀证的临床效果[J].世界中医药,2019,(07):. |
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| 四君子汤加减治疗慢性心力衰竭气虚痰瘀证的临床效果 |
| Clinical Research on Modified Sijunzi Decoction in Treatment of Chronic Heart Failure with Qi Deficiency and Phlegm-stasis Syndrome |
| 投稿时间：2018-06-27 |
| DOI：10.3969/j.issn.1673-7202.2019.07.042 |
| 中文关键词: 四君子汤 慢性心力衰竭 气虚痰瘀证 辨证论治 中医学 心力衰竭 心室功能 6 min步行试验 |
| English Keywords:Modified Sijunzi Decoction Chronic heart failure qi deficiency and phlegm-stasis syndrome Syndrome differentiation and treatment Traditional Chinese medicine Heart failure Ventricular function 6 minute walking test |
| 基金项目:沈阳市科技局社会发展科学基金资助项目(122331) |
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| 中文摘要: |
| 目的：探讨四君子汤加减治疗慢性心力衰竭气虚痰瘀证的临床疗效。方法：选取2017年1月至2017年12月辽宁中医药大学附属医院收治的新诊断慢性心力衰竭气虚痰瘀证患者120例作为研究对象，按照随机数字表法分为对照组和观察组，每组60例。对照组依那普利联合美托洛尔治疗，观察组在此基础上给予四君子汤加减治疗。观察2组患者基线期及治疗后心室功能指标、中医证候积分和6 min步行试验变化，评价患者临床疗效。结果：观察组临床治疗有效率显著高于对照组，差异有统计学意义（P<0.05）。基线期，2组心室功能指标、中医证候积分和6 min步行试验比较，差异无统计学意义（P>0.05）；治疗后，观察组中医证候积分、左室舒张末期内径（LVEDD）、左室收缩末期内径（LVESD）显著低于对照组，观察组6 min步行试验和左室射血分数（LVEF）显著高于对照组，差异有统计学意义（P<0.05）。2组治疗后LVEDD、LVESD和中医证候积分显著低于基线期，差异有统计学意义（P<0.05）；2组治疗后LVEF和6 min步行试验显著高于基线期，差异有统计学意义（P<0.05）。结论：四君子汤加减对慢性心力衰竭气虚痰瘀证患者具有良好的辨证治疗效果。 |
| English Summary: |
| To discuss the clinical efficacy of modified Sijunzi Decoction in treatment of chronic heart failure with qi deficiency and phlegm-stasis syndrome.Methods：A total of 120 patients with chronic heart failure of qi deficiency and phlegm-stasis syndrome were selected in the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from January 2017 to December 2017and were divided into an observation group and a control group according to the random number table method，with 60 cases in each group.The control group received Enalapril combined with metoprolol treatment，and the modified Sijunzi Decoction was added in the observation group.Changes in the indexes of ventricular function，traditional Chinese medicine syndrome score and 6 min walking test of the 2 groups were observed at baseline phase and after treatment.The clinical efficacy was evaluated.Results：The effective rate of the observation group was higher than the control group，and the difference was statistically significant(P<0.05); At baseline phase，there was no statistically significant difference in the indexes of ventricular function，traditional Chinese medicine syndrome score and 6 min walking test(P>0.05); After treatment，traditional Chinese medicine syndrome score，LVEDD and LVESD of the observation group was significantly lower than the control group.The 6 min walking test and LVEF of the observation group was higher than the control group，with statistically significant difference(P<0.05).Traditional Chinese medicine syndrome score，LVEDD and LVESD of the 2 groups after treatment was significantly lower than that baseline phase(P<0.05); 6 min walking test and LVEF of the 2 groups after treatment was significantly higher than that at baseline phase，with statistically significant difference(P<0.05).Conclusion：Modified Sijunzi Decoction for patients with chronic heart failure with qi deficiency and phlegm-stasis syndrome has a good effect of syndrome differentiation and treatment. |
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