世界中医药
文章摘要
引用本文:黄辉1,蔡敏1,单魁中2.温阳利水方治疗慢性肺源性心脏病患者疗效观察[J].世界中医药,2019,(07):.  
温阳利水方治疗慢性肺源性心脏病患者疗效观察
Curative Effects Observation on Wenyang Lishui Decoction in Patients with Chronic Pulmonary Heart Disease and its Effects on HIF-1α,NT-proBNP,hs-CRP and Serum Uric Acid Level
投稿时间:2018-05-07  
DOI:10.3969/j.issn.1673-7202.2019.07.043
中文关键词:  温阳利水方  慢性肺源性心脏病  疗效  血气分析  缺氧诱导因子-1α  N-脑钠肽前体  血尿酸  超敏C反应蛋白
English Keywords:Wenyang Lishui Decoction  Chronic pulmonary heart disease  Curative effect  Blood gas analysis  Hypoxia inducible factor-1α  N-brain natriuretic peptide  Blood uric acid  High sensitivity C reactive protein
基金项目:2017年苏州市吴门医派研究专项科研基金科技项目(SYSD2017202)
作者单位
黄辉1,蔡敏1,单魁中2 1 昆山市中医医院呼吸科,昆山,215300
2 昆山市第二人民医院呼吸科,昆山,215300 
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中文摘要:
      目的:探讨温阳利水方治疗慢性肺源性心脏病患者疗效观察及对患者缺氧诱导因子-1α(HIF-1α)、N-脑钠肽前体(NT-proBNP)、血尿酸和超敏C反应蛋白(hs-CRP)水平影响研究。方法:选取2017年1月至2018年1月昆山市中医医院收治的慢性肺心病患者94例作为研究对象,按照随机数字表法分为对照组与观察组,每组47例。对照组采用常规治疗,观察组在对照组基础上结合温阳利水方治疗。2组患者疗程均为2周。比较2组患者治疗疗效,治疗前后主要症状评分、肺功能、血气分析及血浆HIF-1α、NT-proBNP、血尿酸和hs-CRP水平变化。结果:治疗后,观察组总有效率(93.62%)高于对照组(74.47%)(P<0.05);咳嗽、咳痰和气喘症状评分低于对照组(t=18.217、23.793、27.635,P<0.05)。观察组FEV1和FEV1/FVC高于对照组(t=10.191、6.977,P<0.05);PaO2高于对照组而PaCO2低于对照组(t=7.020、14.221,P<0.05)。观察组治疗后血浆HIF-1α、NT-proBNP、血尿酸和hs-CRP水平低于对照组(t=43.131、32.302、19.930、18.097,P<0.05)。结论:温阳利水方治疗慢性肺源性心脏病患者疗效显著,可降低患者血浆HIF-1α、NT-proBNP、血尿酸和hs-CRP水平,值得临床推广。
English Summary:
      To investigate the curative effect of Wenyang Lishui Decoction in the treatment of patients with chronic pulmonary heart disease and its effects on patients' hypoxia inducible factor-1α(HIF-1α),N-brain natriuretic peptide(NT-proBNP),blood uric acid and high sensitive C reactive protein(hs-CRP)level.Methods:From January 2017 to January 2018,94 patients with chronic pulmonary heart disease in Kunshan Traditional Chinese Medicine Hospital were selected and divided into an observation group(47 cases)and a control group(47 cases)according to random number table.The control group received routine treatment,and the observation group in the control group on the basis of Wenyang Lishui treatment.The two groups were treated for 2 weeks.The curative effect of the 2 groups was compared.The main symptom scores,lung function,blood gas analysis and the changes of plasma HIF-1α,NT-proBNP,serum uric acid and hs-CRP levels before and after the treatment were compared.Results:After treatment,the total effective rate in the observation group(93.62%)was higher than the control group(74.47%)(P<0.05).The scores for cough,expectoration,and asthma were lower than the control group(t=18.217,23.793,27.635,P<0.05).The FEV1 and FEV1/FVC in the observation group were higher than those in the control group(t=10.191,6.977,P<0.05).PaO2 in the observation group was higher than that in the control group,while PaCO2 in the control group was lower than that in the control group(t=7.020,14.221,P<0.05).The plasma HIF-1α,NT-proBNP,blood uric acid and hs-CRP levels in the observation group than in the control group(t=43.131,32.302 19.930,18.097,P<0.05).Conclusion:Wenyang Lishui Decoction is significantly effective in the treatment of chronic pulmonary heart disease patients,which can reduce the plasma levels of HIF-1α,NT-proBNP,hs-CRP and serum uric acid level.It is worthy of clinical promotion.
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