| To explore the clinical efficay of balanced acupuncture combined with Chaihu Shugan Powder on diabetic painful peripheral neuropathy(DPN),and to study its mechanism of action in order to precise treatment.Methods：A total of 102 patients with DPN who met the inclusion criteria were enrolled as research subjects in Chaoyang District Hospital of Traditional Chinese Medicine in Beijing from January 2013 to January 2017.They were randomly divided into control group(51 cases）and observation group(51 cases）according to their numbers of treating order.The control group was treated with routine western medicine,while the observation group was treated with routine western medicine plus balanced acupuncture combined with Chaihu Shugan Powder,both for 4 weeks.The changes of fasting blood glucose(FBG),postprandial blood glucose after 2 h(2 hPBG）and glycosylated hemoglobin(HbA1c）levels before and after the treatment were observed and compared between the 2 groups.The motor nerve conduction velocity(MCV）and sensory nerve conduction velocity(SCV）of median nerve,common peroneal nerve and posterior tibial nerve were observed and compared before and after the treatment between the 2 groups.The changes of hemorheological indexes such as whole blood high shear viscosity(HSV),whole blood low shear viscosity(LSV),plasma viscosity(PSV),hematocrit(HCT),platelet aggregation rate before and after the treatment were observed and compared between the 2 groups.The content changes of C-reactive proteinen(CRP),dothelin-1(ET-1),propylene glycol(MDA）and superoxide dismutase(SOD）were observed and compared before and after the treatment between the 2 groups.The changes of white blood cell(WBC),alanine transaminase(ALT),creatinine(Cr),hemoglobin(Hb）and platelet(PLT）were observed and compared before and after the treatment between the 2 groups.Results：1）There were comparable differences in the FBG,2 hPBG and HbA1c between the 2 groups before the treatment(P>0.05).After the treatment,the FBG,2 hPBG and HbA1c in the 2 groups were decreased significantly compared with those before the treatment(P<0.05).After the treatment,the above indexes in the observation group were significantly lower than those in the control group(P<0.05). 2）The MCV and SCV of median nerve,common peroneal nerve,posterior tibial nerve in the 2 groups were comparable before the treatment(P>0.05).After the treatment,the above indexes of the 2 groups were significantly higher than those before the treatment(P<0.05).After the treatment,the above indexes of the observation group were significantly higher than those of the control group(P<0.05). 3）There were comparable differences in the CRP,ET-1,MDA and SOD between the 2 groups before the treatment(P>0.05).After the treatment,the CRP,ET-1 and MDA in the 2 groups were decreased significantly compared with those before the treatment,while the SOD was increased significantly compared with those before the treatment(P<0.05).After the treatment,the CRP,ET-1 and MDA in the observation group were significantly lower than those in the control group,and SOD was significantly higher than that in the control group(P<0.05). 4）There were comparable differences in the HSV,LSV,PSV,HCT and platelet aggregation rate between the 2 groups before the treatment(P>0.05).After the treatment,the above indexes of the 2 groups were significantly lower than those of the control group(P<0.05).After the treatment,the above indexes of the observation group were significantly lower than those of the control group(P<0.05). 5）There was no significant change in the WBC,ALT,Cr,Hb and PLT between the 2 groups before and after the treatment,without statistically significant difference(P>0.05).Conclusion：Balanced acupuncture combined with Chaihu Shugan Powder can improve hemorheology,inhibit oxidative stress reaction,scavenge oxygen free radicals,and increase sensory and motor nerve conduction velocity in DPN patients,thereby improving clinical symptoms and reducing blood sugar,with high safety. |
