| To analyze the compatibility rule of Chinese Prescription Database in the treatment of constipation,and to provide basis for clinical treatment of constipation.Methods:Based on the screening of formula in the treatment of constipation in the Chinese Prescription Database,we collected and analyzed the prescription by frequency analysis,factor analysis,system clustering,association rule analysis and other data mining methods.Results:A total of 287 prescriptions for constipation were screened,involving 211 Chinese herbs,and the most frequent one was Radix Glycyrrhizae(109 times),followed by Radix et Rhizoma Rhei(103 times).Factor analysis can extract 25 principal components.The cluster number of 5 kinds was good,and commonly used drugs were Radix et Rhizoma Rhei,Radix Scutellariae,Radix Angelicae Sinensis,Paeonia Lactiflora,Pericarpium Citri Reticulatae,Radix Aucklandiae,Radix Rehmanniae Recens,Radix Ginseng,etc.,and 10 core combinations were obtained.The correlation analysis showed that Radix et Rhizoma Rhei combined with Radix Scutellariae and Fructus Gardeniae; Radix et Rhizoma Rhei with Natrii Sulfas; Radix Glycyrrhizae with Fructus Gardeniae and Radix Scutellariae; Radix et Rhizoma Rhei with Rhizoma Coptidis were known drug pair.Conclusion:The drugs of formula for constipation in Chinese Prescription Database were mainly tonifying deficiency,relieving superficies,clearing away heat,regulating qi,purging purgation and eliminating phlegm and relieving wheezing.And Radix et Rhizoma Rhei→ Semen Arecae; Radix Angelicae Sinensis→ Radix Rehmanniae Recens; Radix Glycyrrhizae→ Pericarpium Citri Reticulatae; Rhizoma et Radix Notopterygii→ Radix Saposhnikoviae; Paeonia Lactiflora→Radix Angelicae Sinensis are worthy of further discussion,which will provide some reference for the research and development of new drugs of TCM for constipation. |
