To systematically collect,sort out and excavate prescriptions of Fructus Schisandrae Chinensis in TCM Formula Database by data mining technology,and to explore the application and compatibility rules.Methods:Based on TCM Formula Database,the prescriptions containing Fructus Schisandrae Chinensis was screened out and collected.With the aid of the IBM SPSS Statistics with IBM SPSS Modeler 190 142 data mining software,the frequency,nature,flavor,channel tropism,indication analysis,factor analysis,association rules analysis were conducted,thus its basic drugs and drug compatibility law was analyzed.Results:A total of 631 prescriptions related to Fructus Schisandrae Chinensis were screened.In addition to Fructus Schisandrae Chinensis,a total of 217 traditional Chinese medicines were involved,with totally 16 kinds of traditional Chinese medicines used.The top 3 kinds of drugs used most frequently were deficiency tonifying,phlegm-resolving,cough-relieving and asthma-relieving drugs and superficies-relieving drugs.Fructus Schisandrae Chinensis was often combined with warm,sweet and bitter medicines.Fructus Schisandrae Chinensis was commonly used in the prescriptions for the treatment of pulmonary diseases,with a frequency as high as 5509%,followed by spleen-stomach diseases.The dosage ratio of Fructus Schisandrae Chinensis and some high-frequency drugs was usually 1:1.By factor analysis of high frequency drugs,23 common factors were extracted.The analysis of association rules showed that 39 pairs of drugs with Fructus Schisandrae Chinensis and drug groups containing Fructus Schisandrae Chinensis were obtained,including 20 pairs of binary matrices,13 ternary matrices and 6 quaternion matrices.Conclusion:Through discussing the prescription containing Fructus Schisandrae Chinensis and its compatibility with Fructus Schisandrae Chinensis,the herbs that often combined with Fructus Schisandrae Chinensis are deficiency tonifying,and the prescriptions consisting of Fructus Schisandrae Chinensis are mostly used to treat pulmonary diseases.Factor analysis shows that 23 common factors can be generalized as Chinese medicine which is often compatible with Fructus Schisandrae Chinensis.The association rules showed that Fructus Schisandrae Chinensis→Radix Ginseng,Radix Glycyrrhizae,and Fructus Schisandrae Chinensis,Poria,Radix Ginseng,Radix Glycyrrhizae and so on were the commonly used medication groups.These not only embody the rules of physician's principles,methods,prescriptions,medicines and syndrome differentiation,but also provide reference for modern physician's prescription medication and new drug development. |