| 引用本文:霍健1，刘焕1，苏兴利1，赵妍1，李春燕2.参苓白术散加减对肺癌术后慢性咳嗽的疗效及相关机制研究[J].世界中医药,2019,(09):. |
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| 参苓白术散加减对肺癌术后慢性咳嗽的疗效及相关机制研究 |
| Effects of Modified Shenling Baizhu Powder on Chronic Cough after Lung Cancer Operation and Its Related Mechanisms |
| 投稿时间：2019-02-01 |
| DOI：10.3969/j.issn.1673-7202.2019.09.016 |
| 中文关键词: 参苓白术散 复方甲氧那明 肺癌术后咳嗽 疗效 肺功能 机制 血清炎性反应因子 免疫 |
| English Keywords:Shenling Baizhu Powder Compound methoxynamine Cough after lung cancer surgery Therapeutic effect Lung function Mechanisms Serum inflammatory factors Immunity |
| 基金项目:国家自然科学基金青年项目（81501175） |
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| 中文摘要: |
| 目的：观察参苓白术散加减对肺癌术后咳嗽的疗效，并探讨其相关机制。方法：选取2013年7月至2017年12月陕西省肿瘤医院收治的肺癌术后咳嗽患者142例作为研究对象，按照随机数字表法分为对照组和观察组，每组71例。对照组给予复方甲氧那明口服，2粒/次，3次/d；观察组在对照组治疗的基础上给予参苓白术散加减，每日1剂，200 mL温服分服，2组均连续治疗2周，疗程结束后观察2组的临床疗效、血清炎性反应因子（PCT、CRP、IL-6、IL-8、TNF-α）、肺功能（VC、FEV1、FEV1/FVC、MMEF、PEF）及免疫功能（IgA、IgM、IgG、补体C3、补体C4）的变化。结果：1）观察组治疗有效率为88.73%，对照组为74.65%，2组比较差异有统计学意义（P<0.05）；2）治疗后2组患者不同维度的LCQ-MC评分及LCQ-MC总分均较治疗前升高（P<0.05），其中观察组升高趋势较对照组明显（P<0.05）；3）治疗后2组患者外周血清PCT、CRP、IL-6、IL-8、TNF-α浓度均较治疗前有所下降（P<0.05），其中观察组下降的趋势更为明显，与对照组比较差异有统计学意义（P<0.05）；4）肺功能：治疗后2组VC、FEV1、FEV1/FVC、MMEF、PEF均较治疗前上升（P<0.05），其中观察组改善较对照组明显（P<0.05）；5）免疫功能：治疗后2组IgA、IgM、IgG、补体C3、补体C4水平较治疗前明显升高（P<0.05），其中观察组升高幅度高于对照组（P<0.05）。结论：参苓白术散加减可明显改善肺癌术后咳嗽患者的临床症状，进一步提升其肺功能，其作用机制可能与降低血清炎性反应因子，提高机体免疫力有关。 |
| English Summary: |
| To observe the effects of modified Shenling Baizhu Powder on cough after lung cancer surgery，and to explore its related mechanism.Methods:A total of 142 patients with cough after lung cancer operation in Shaanxi Cancer Hospital from July 2013 to December 2017 were divided into a control group and an observation group according to random number table method，with 71 cases each.The control group was given compound methoxynamine orally，2 capsules per time，3 times per day; the observation group was given Shenling Baizhu Powder on the basis of the control group，one dose per day，200 mL warm decoction.Two groups were treated for 2 weeks continuously.After the treatment，the changes of clinical efficacy，serum inflammatory factors(PCT，CRP，IL-6，IL-8，TNF-α)，lung function(VC，FEV1，FEV1/FVC，MMEF，PEF)and immune function(IgA，IgM，IgG，complement C3，complement C4)of the 2 groups were observed.Results: 1)Clinical efficacy：the effective rate of the observation group was 88.73%，which was significantly different from 74.65% of the control group(P<0.05). 2)After treatment，the LCQ-MC scores and total LCQ-MC scores of the 2 groups in different dimensions were increased than those before treatment(P<0.05)，and the rising trend of the observation group was more obvious than that of the control group(P<0.05). 3)Serum inflammatory factors：After treatment，the concentration of PCT，CRP，IL-6，IL-8 and TNF-α in peripheral serum of the 2 groups decreased compared with that before treatment(P<0.05)，and the tread of decrease in the observation group was more significant，with statistical significance compared with the control group(P<0.05). 4)Pulmonary function：After treatment，the concentration of VC，FEV1，FEV1/FVC，MMEF and PEF in the 2 groups increased compared with that before treatment(P<0.05)，and the improvement in the observation group was more significant than in the control group(P<0.05). 5)Immune function：After treatment，the levels of IgA，IgM，IgG，complement C3 and complement C4 in the 2 groups were significantly increased than those before treatment(P<0.05)，and the increase in the observation group was higher than that in the control group(P<0.05).Conclusion:Modified Shenling Baizhu Powder can significantly improve the clinical symptoms and lung function of patients with cough after lung cancer surgery，and its mechanism may be related to the reduction of serum inflammatory factors and the improvement of body immunity. |
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