世界中医药

目的：探讨归芪活血胶囊联合硫酸氨基葡萄糖对颈椎病的治疗效果。方法：选取2016年6月至2018年6月青海大学附属医院收治的颈椎病患者100例作为研究对象，随机分为对照组和观察组，每组50例。对照组患者口服硫酸氨基葡萄糖，2次/d，500 mg/次；观察组在对照组基础上口服归芪活血胶囊，1粒/次，3次/d，2组均连续治疗1个月。通过治疗后临床疗效，X线片检测治疗前后颈椎弧度变化；经颅多普勒(TCD)检测治疗前后基底动脉（BA）和左右双侧椎动脉（LVA和RVA）血流速度变化评价2组的治疗效果。结果：观察组临床总有效率达到96%，无效率仅为4%；对照组总有效率达到84%，无效率为6%，观察组效果显著优于对照组，2组比较差异有统计学意义（P<0.05）。2组治疗后颈椎弧度均有改善，观察组增大到（11.62±3.78）mm，2组比较差异有统计学意义（P<0.05）。治疗后2组基底动脉和左右双侧椎动脉血流速度均有改善，2组治疗前后比较，差异均有统计学意义（P<0.05），观察组效果优于对照组，2组比较差异有统计学意义（P<0.05）。结论：归芪活血胶囊联合硫酸氨基葡萄糖对颈椎病效果显著，适合推广。

English Summary:

To investigate the therapeutic effect of Guiqi Huoxue Capsule combined with glucosamine sulfate in the treatment of cervical spondylosis.Methods:A total of 100 patients with cervical spondylosis admitted to Qinghai University Affiliated Hospital from June 2016 to June 2018 were randomly divided into a control group and an observation group,with 50 patients in each group.Patients in the control group were given oral glucosamine sulfate twice a day,500 mg each time,for one month.The observation group was given oral Guiqi Huoxue Capsule on the basis of the control group,3 times a day,one capsule at a time.Both groups were treated continuously for one month.The clinical efficacy was observed after treatment.X-ray was used to exam cervical spine radian changes before and after treatment.Transcranial doppler(TCD)was used to detect the changes of blood flow velocity in basilar artery(BA)and bilateral vertebral artery(LVA and RVA)before and after treatment were used to evaluate the therapeutic effect of 2 groups.Results:The total effective rate in the observation group was 96% and the ineffective rate was only 4%.The effective rate of the control group was 86%,and the ineffective rate was 14%.The effect of the observation group was significantly better than that of the control group,and the difference between the 2 groups had statistical significance(P<0.05).After treatment,the curvature of the cervical spine in the treatment group improved to(11.62±3.78)mm and the difference between the 2 groups was statistically significant(P<0.05).After treatment,the blood flow velocity of basilar artery and bilateral vertebral artery was improved in both groups,and there was significant difference between the 2 groups before and after treatment(P<0.05).The effect of the observation group was better than the control group and the difference has statistical significance(P<0.05).Conclusion:Guiqi Huoxue Capsule combined with glucosamine sulfate has a significant effect on cervical spondylosis which is suitable for promotion.

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