| 引用本文:程国良1，张春铭2，林佳如3.人参固本口服液联合泼尼松治疗成人肾病综合征的疗效观察[J].世界中医药,2019,(09):. |
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| 人参固本口服液联合泼尼松治疗成人肾病综合征的疗效观察 |
| Observation on the Therapeutic Effect of Renshen Guben Oral Liquid Combined with Prednisone in the Treatment of Nephrotic Syndrome |
| 投稿时间：2019-03-02 |
| DOI：10.3969/j.issn.1673-7202.2019.09.022 |
| 中文关键词: 肾病综合征 人参固本口服液 泼尼松 临床研究 有效率 不良反应 蛋白尿 低蛋白血症 高脂血症 |
| English Keywords:Nephrotic syndrome Ginseng Guben oral liquid Prednisone Clinical study Effective rate Adverse reactions Albuminuria Hypoalbuminemia Hyperlipidemia |
| 基金项目:国家自然科学基金项目（81173434）——基于差异蛋白组学的肾康灵治疗原发性肾病综合征的机制研究 |
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| 中文摘要: |
| 目的：探讨人参固本口服液联合泼尼松治疗成人肾病综合征的疗效，为临床治疗提供参考。方法：选取2017年3月至2018年2月西南医科大学附属医院肾病内科收治的肾病综合征患者108例作为研究对象，随机分为对照组、观察组A（低剂量组）和观察组B（高剂量组），每组36例。对照组患者给予泼尼松治疗，初始剂量1.0 mg/(kg·d),最大剂量60 mg/d，尿蛋白转阴或每日最大剂量服用4周后减量，每周减少10%剂量，直至调至20 mg/d，并在2个月后减量至10 mg/d，以10 mg/d维持至疗程结束。观察组A在对照组基础上，给予口服人参固本口服液治疗，每次餐前口服10 mL，2次/d,1周后减量至1次/d，继续服用1周后减量，口服5 mL/次，隔日顿服，并以此剂量维持至疗程结束。观察组B在对照组基础上，给予口服人参固本口服液治疗，每次餐前口服10 mL，2次/d,1周后减量至1次/d，并以此剂量维持至疗程结束。观察组A和观察组B的疗程均为1个月。比较3组的治疗效果。结果：3组患者在疗程结束后总治愈率有明显差别，观察组A和观察组B的总有效率分别为94.44%、97.22%，均优于对照组的总有效率77.22%，差异有统计学意义（P<0.05）。但观察组A和观察组B总有效率比较，差异无统计学意义（P>0.05）。观察组A和观察组B患者的尿液蛋白指标和血脂水平均低于对照组，差异有统计学意义（P<0.05）。但观察组A、观察组B的尿液蛋白指标和血脂水平比较，差异无统计学意义（P>0.05）。观察组A不良反应发生率比观察组B低，差异无统计学意义（P>0.05）。结论：人参固本口服液联合泼尼松治疗肾病综合征的疗效显著，明显优于泼尼松单独治疗。但临床建议使用低剂量的人参固本口服液联合泼尼松治疗肾病综合征。 |
| English Summary: |
| To observe the therapeutic effects of Renshen Guben Oral Liquid combined with prednisone in the treatment of nephrotic syndrome and to provide references for clinical medicine.Methods:From March 2017 to Feburary 2018,108 patients with nephrotic syndrome admitted by The Affiliated Hospital of Southwest Medical University were randomly divided into 3 groups-a control group,a low dose observation group A and a high dose observation group B,with 36 patients in each group.Patients in the control group received the treatment of prednisone and initial dose of prednisone,which was less than 60 mg/d,was 1.0 mg/(kg·d).Daily dose reduced 10% per week to 20 mg/d,which would be maintained for 2 months,when urine test showed urine protein,or 4 weeks later.After daily dose of 20 mg,dose of 10 mg/d would be maintained until the end of the course.Patients in low dose observation group A received the treatment of low dose of Renshen Guben Oral Liquid on the basis of the same treatment of prednisone in control group.During first week,initial dose of Renshen Guben Oral Liquid was 10 mL at a time,twice per day.Daily dose would be once per day during the second week.After that,the dose reduced to 5 mL at a time in 2 days for the last 2 weeks of the course.Patients in high dose observation group B received the treatment of high dose of Renshen Guben Oral Liquid besides the same treatment of prednisone in control group.During first week,initial dose of Renshen Guben Oral Liquid was 10 mL,twice per day.After that,daily dose would be 10 mL,which would be maintained until the end of the course.Results:The difference of cure rate among the 3 groups was significant.The total cure rates of the observation group A and B were 94.44% and 97.22% respectively,which were better than those of control group 77.22%.The difference was statistically significant(P<0.05),while the difference between the 2 observation groups was not statistically significant(P>0.05).There were also significant differences of 24-hour urine protein quantitation,BUN,TC and TG among the 3 groups.The difference between group A and group B was still not statistically significant(P>0.05).As for the adverse reactions in test groups,the incidence of group A was lower than that of group B.Conclusion:Therapeutic effect of Renshen Guben Oral Liquid combined with prednisone is better than prednisone alone in the treatment of nephrotic syndrome.However,low dose of Renshen Guben Oral Liquid is recommended to combine with prednisone in the treatment of nephrotic syndrome. |
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