| 引用本文:王瑞平，薛闪，施书芳，曹西田，刘维旭，刘建民，贺艳光，段利民.软坚散结活血行气法对肾功能不全代偿期及失代偿期的多囊肾患者的治疗效果研究[J].世界中医药,2019,(09):. |
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| 软坚散结活血行气法对肾功能不全代偿期及失代偿期的多囊肾患者的治疗效果研究 |
| Study on Efficacy of Softening Hardness, Dissipating Masses, Invigorating Blood and Moving Qi Method in Polycystic Kidney Disease Patients at the Stage of Compensation Period and Decompensation Period of Renal Insufficiency |
| 投稿时间：2018-08-21 |
| DOI：10.3969/j.issn.1673-7202.2019.09.036 |
| 中文关键词: 中医 软坚散结 活血行气 肾功能不全 代偿期 失代偿期 多囊肾 血肌酐 |
| English Keywords:Traditional Chinese medicine Softening hardness and dissipating masses Invigorating blood and moving qi Compensation period Decompensation period Polycystic kidney Blood creatinine |
| 基金项目:石家庄市科学技术研究与发展指导计划（1714614303） |
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| 中文摘要: |
| 目的：探讨软坚散结活血行气法对肾功能不全代偿期及失代偿期的多囊肾患者的治疗效果研究。方法：选取2016年6月至2017年6月石家庄肾病医院收治的肾功能不全的多囊肾患者150例作为研究对象,按照随机数字的方法将患者分为对照组和观察组，每组75例，对照组患者使用常规西医治疗方法，观察组在对照组患者治疗方案基础上使用软坚散结活血行气法进行治疗，对治疗的效果进行比较。结果：经过治疗后，对照组患者的血肌酐、尿酸、肾小球滤过率等肾功能指标均有所改善，肾脏体积和最大囊肿直径有所增大，观察组患者的血肌酐、尿酸、肾小球滤过率等肾功能指标均有明显改善，肾脏体积、最大囊肿直径均减小，观察组患者的改善幅度大于对照组患者，数据差异均有统计学意义（P<0.05），所有项目的处理因素与时间均存在交互作用（P<0.05），观察组患者的治疗效果优于对照组患者，数据差异有统计学意义（Z=-5.685，P<0.05），2组患者的各类不良反应发生率的数据差异均无统计学意义（χ2=0.150，0.694，0.340，1.027，0.207，0.528，P>0.05）。结论：利用软坚散结活血行气法对肾功能不全代偿期及失代偿期的多囊肾患者进行治疗，可以明显改善血肌酐，尿酸，肾小球滤过率血红蛋白，肾脏体积，最大囊肿直径的水平，提升治疗效果，值得在临床工作中使用。 |
| English Summary: |
| To explore the efficacy of softening hardness, dissipating masses, invigorating blood and moving qi method in polycystic kidney disease patients at the stage of compensation period and decompensation period of renal insufficiency.Methods:A total of 150 patients of polycystic kidney disease with renal insufficiency treated in the Shijiazhuang Kidney Disease Hospital between June 2016 and June 2017 were selected as research objects.They were randomly divided into a control group and an observation group, with 75 patients in each group.The patients in the control group were treated with routine western medicine, and the patients in the observation group were additionally treated with softening hardness, dissipating masses, invigorating blood and moving qi method base on the treatment in the control group.The efficacy in the 2 groups was compared.Results:After the treatment, renal functional parameters like serum creatinine, uric acid and glomerular filtration rate in the control group were improved, and its kidney volume and the maximum cyst diameter were increased.In the observation group, the renal functional parameters like serum creatinine, uric acid and glomerular filtration rate were obviously improved, and the kidney volume and the maximum cyst diameter were decreased.The improvement in the observation group was greater than that in the control group, and the difference was statistically significant(P<0.05).There were interactions between treatment factors and time in all the items(P<0.05).The efficacy in the observation group was better than that in the control group, and the difference was statistically significant(Z=-5.685, P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the 2 groups(χ2=0.150, 0.694, 0.340, 1.027, 0.207 and 0.528, P>0.05).Conclusion:Treatment of polycystic kidney disease with renal insufficiency at the stage of compensation period and decompensation period by softening hardness, dissipating masses, invigorating blood and moving qi method can significantly improve the levels of serum creatinine, uric acid and glomerular filtration rate, hemoglobin, renal volume and maximum cyst diameter, and enhance the efficacy, which is worthy of clinical application. |
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