世界中医药

目的:观察益气降湿降浊汤加减治疗糖尿病肾病的疗效及其对肾功能、血管内皮功能、血液流变学及血清炎性反应因子的影响。方法:选取2016年7月至2018年12月湖北医药学院附属人民医院收治的糖尿病肾病患者164例作为研究对象,按照随机数字表法分为对照组和观察组,每组82例。对照组给予前列地尔联合贝那普利治疗,观察组在对照组治疗的基础上加用益气利湿降浊汤,观察2组患者的临床疗效及治疗前后血液流变学指标、血管内皮功能、肾功能及血清炎性反应因子变化情况。结果:治疗后,2组患者红细胞比积、血胆固醇、三酰甘油、蛋白尿、血浆纤维蛋白原、全血黏度高切、全血黏度低切、血浆黏度、血尿素氮、肌酐、TNF-α、IL-6、CRP、ET-1水平明显降低,血白蛋白、NO水平明显升高,观察组上述指标变化更明显,差异有统计学意义(P<0.05)。观察组治疗后的总有效率(90.24%)明显高于对照组(78.05%),差异有统计学意义。结论:益气利湿降浊汤可通过降低血清炎性反应因子,改善血管内皮功能,纠正血流动力学异常,从而提高糖尿病肾病的临床治疗效果。

English Summary:

To observe the the clinical effect of Yiqi Lishi Jiangzhuo Soup in the treatment of diabetic nephropathy and the influence on renal function,the vascular endothelial function,the serum inflammatory factors and the blood rheology.Methods:A total of 164 cases with diabetic nephropathy were divided into the control group and the observational group,82 cases of each group.The control group was given alprostadil and benazepril.The observational group was given Yiqi Lishi Jiangzhuo Soup based on the treatment of the control group.The clinical effect,the renal function,the vascular endothelial function,the serum inflammatory factors and the blood rheology were observed of two groups.Results:After treatment,the red blood corpuscle,blood cholesterol,triglyceride,proteinuria,plasma fibrinogen,whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity,blood urea nitrogen,creatinine,TNF-α,IL-6,CRP,ET-1 were decreased of two groups.The level of NO,blood albumin increased significantly.The above indexes of the observational group changed more obvious,the differences were statistically significant(P<0.05).The total effective rate of the observational group(90.24%)was higher than the control group(78.05%),the difference was statistically significant.Conclusion:Yiqi Lishi Jiangzhuo Soup can reduce the serum level of the inflammatory cytokines,improve endothelial function,adjust hemodynamic abnormalities,so as to improve the clinical therapeutic effect of diabetic nephropathy.

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