世界中医药

目的：探讨扶正消瘀汤对糖尿病下肢动脉血管病变的血脂APN及血流状况的影响。方法：选取2015年3月至2016年3月荆门市第二人民医院收治的糖尿病下肢血管病变患者100例作为研究对象，按照患者入院ID号尾号随机分为对照组和观察组，每组50例。对照组采取常规治疗，观察组在对照组的基础上，采用扶正消瘀汤治疗，对2组患者治疗后的疗效、治疗前后的血液流变学及血清C反应蛋白（CＲP）、白细胞介素6（IL-6）、肿瘤坏死因子α（TNF-α）、血脂脂联素（APN）、踝肱指数、足背动脉血流量以及不良反应进行比较分析。结果：治疗前，2组患者的血脂APN比较，差异无统计学意义（P>0.05）；治疗后，观察组的血脂APN明显高于对照组，2组比较差异有统计学意义（P<0.05）。观察组患者的总有效率（94.00%）明显小于对照组（80.00%），治疗前，2组患者的全血低、高切黏度以及血浆黏度比较，差异无统计学意义（P>0.05）；治疗后，全血低、高切黏度以及血浆黏度明显低于对照组，CＲP、IL-6、TNF-α水平均明显低于对照组，2组比较差异有统计学意义（P<0.05）。治疗前，2组患者的踝肱指数和足背动脉血流量比较，差异无统计学意义（P>0.05）。治疗后，观察组的踝肱指数和足背动脉血流量均明显高于对照组，2组比较差异有统计学意义（P<0.05）。结论:对糖尿病下肢血管病变患者采取扶正消瘀汤治疗，能够提高临床疗效，改善患者血液流变学及血清水平，同时提高血脂APN水平，降低不良反应的发生率，值得临床上应用及推广。

English Summary:

To investigate the effect of Fuzheng Xiaoyu Decoction on blood lipid APN and blood flow in diabetic lower extremity arterial vascular lesions.Methods:A total of 100 patients with diabetic lower extremity vascular disease in Jingmen Second People's Hospital were selected from March 2015 to March 2016.According to the number of the patients' entrance number ID，the patients were randomly divided into a control group and an observation group.The control group was treated with routine treatment，and the observation group was treated with Fuzheng Xiaoyu Decoction on the basis of the control group.The curative effects of the 2 groups of patients after treatment，and the blood rheology and serum C reactive protein(CRP)，interleukin 6(IL-6)，tumor necrosis factor α(TNF-α)，blood lipid adiponectin(APN)，ankle brachial index，dorsal artery blood flow and adverse reactions of the 2 groups were compared and analyzed.Results:Before treatment，there was no significant difference in blood lipid APN between the 2 groups(P>0.05).After treatment，the serum lipid APN of the observation group was significantly higher than that of the control group，and the difference between the 2 groups was statistically significant(P<0.05).The total efficiency of the observation group(94%）was significantly lower than the control group(80%).Before treatment，the 2 groups had no statistically significant difference in low and high blood viscosity，plasma viscosity(P>0.05); after treatment，whole blood low and high viscosity and plasma viscosity was significantly lower than the control group，and CRP，IL-6，TNF-α level of these indicators before treatment were significantly lower than control group.There was significant difference between the 2 groups(P<0.05).Before treatment，there was no significant difference in the ankle brachial index and the blood flow rate of the dorsum of the foot between the 2 groups(P>0.05).After treatment，the ankle brachial index and the blood flow rate of the dorsum pedis artery of the observation group were significantly higher than those in the control group，and the difference between the 2 groups was statistically significant(P<0.05).Conclusion:The treatment of diabetic lower extremity vascular disease by Fuzheng Xiaoyu Decoction can improve the clinical efficacy，improve hemorheology and serum level，increased blood lipid APN level，reduce the incidence of adverse reactions，which is worthy of clinical application and promotion.

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